| ironjustice@aol.com 2005-09-30, 1:11 pm |
| [Reactive oxygen species in inflammatory diseases of the pancreas.A
possible therapeutic target?]
Vaquero-Raya E, Molero-Richard X
Gastroenterol Hepatol. 2005 Oct ; 28(8): 473-84
Chronic and acute pancreatitis can be understood as distinct stages of
an inflammatory spectrum in the pancreas. Although its pathogenesis is
not well defined, oxidative stress seems to be clearly involved in its
development. During acute pancreatitis, there is an extraordinary and
rapid formation of reactive oxygen species that leads to the extinction
of pancreatic antioxidant reserves, causes direct tissue damage and
activates oxidative cellular mediators, giving rise to the lesion.
However, classical antioxidants have not been shown to have clear
benefits in patients with acute pancreatitis. Chronic pancreatitis
seems to be the result of a recurrent lesion and defective repair,
leading to pancreatic atrophy and fibrosis. In this process, oxidative
stress is an efficient stimulus to maintain pancreatic stellar cells
active, the fibrogenic motor of chronic pancreatitis. Although
antioxidant supplements relieve abdominal pain in these patients, the
direction of future antioxidant therapies lies in identifying oxidative
mechanisms with the potential for intervention.
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