|
Home > Archive > Pathology > September 2005 > Iron sucrose injections useful in kidney disease
You are viewing an archived Text-only version of the thread.
To view this thread in it's original format and/or if you want to reply to
this thread please [click here]
| Author |
Iron sucrose injections useful in kidney disease
|
|
| outsor@citynet.net 2005-09-24, 2:11 pm |
| http://www.medscape.com/viewarticle/511791
" NEW YORK (Reuters Health) Aug 29 - An injection of iron sucrose
appears to be a safe way of providing iron to patients with chronic
kidney disease (CKD), new research suggests. Moreover, it takes only
2
minutes to administer and does away with the intravenous fluids and
tubing that are needed with standard iron supplementation methods.
Iron supplementation is a key part of managing anemia in CKD
patients."
| |
| ironjustice@aol.com 2005-09-24, 2:11 pm |
| Kidney Int. 2004 Jun;65(6):2279-89. Related Articles, Links
Oxidative stress and renal injury with intravenous iron in patients
with chronic kidney disease.
Agarwal R, Vasavada N, Sachs NG, Chase S.
Division of Nephrology, Department of Medicine, Indiana University
School of Medicine, and Richard L. Roudebush VA Medical Center,
Indianapolis, 46202, USA. ragarwal@iupui.edu
BACKGROUND: Intravenous iron is widely prescribed in patients with
chronic kidney disease (CKD) and can cause oxidative stress. The
relationship of oxidative stress and renal injury in patients with CKD
is unknown. Whether renal injury can occur at a time point when
transferrin is incompletely saturated is also unclear. METHODS: We
conducted a randomized, open-label, parallel group trial to compare the
oxidative stress induced by intravenous administration of 100 mg iron
sucrose over 5 minutes and its protection with N-acetylcysteine (NAC)
in 20 subjects with stage 3 or 4 CKD. Transferrin saturation was
measured with urea polyacrylamide gel electrophoresis, oxidative stress
by malondialdehyde (MDA) measurement by high-performance liquid
chromatography, and renal injury by enzymuria and proteinuria. Reduced
and oxidized glutathione and free radical scavengers as well as urinary
monocyte chemoattractant protein-1 were also measured. RESULTS:
Parenteral iron increased plasma concentration and urinary excretion
rate of MDA, a biomarker of lipid peroxidation, within 15 to 30 minutes
of iron sucrose administration. This was accompanied by enzymuria and
increase in proteinuria. In contrast, saturation of transferrin was not
maximally seen until 3 hours after the end of infusion. Oxidative
stress, enzymuria and proteinuria were transient and were completely
resolved in 24 hours. NAC reduced acute generation of systemic
oxidative stress but failed to abrogate proteinuria or enzymuria.
CONCLUSION: Intravenous iron produces oxidative stress that is
associated with transient proteinuria and tubular damage. The rapid
production of oxidative stress even when transferrin is not completely
saturation suggests free iron independent mechanism(s) to be operative
in producing oxidative stress and transient renal injury. Long-term
implications of these findings need further study.
Publication Types:
Clinical Trial
Randomized Controlled Trial
PMID: 15149341 [PubMed - indexed for MEDLINE]
--------------------------------------------------------------------------------
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
| |
| outsor@citynet.net 2005-09-24, 2:11 pm |
| Had you read the article closely or at all, the iv method tested in this
article is what they avoid. No way to tell, but they might even applaud
the original article for it's solution to their concerns.
|
| |
|
|