|
Home > Archive > Pathology > September 2005 > Iron chelation / African sleeping sickness
You are viewing an archived Text-only version of the thread.
To view this thread in it's original format and/or if you want to reply to
this thread please [click here]
| Author |
Iron chelation / African sleeping sickness
|
|
| ironjustice@aol.com 2005-09-24, 2:08 pm |
|
Biokemistri
Nigerian Society for Experimental Biology
ISSN: 0795-8080
Vol. 16, No. 2, 2004, pp. 56-63
Bioline Code: bk04020
Biokemistri, Vol. 16, No. 2, 2004, pp. 56-63
Iron chelation excludes protein synthesis inhibition in the
tetracycline management of African trypanosomosis
Justine T. EKANEM, Titilayo O. JOHNSON, Iyabo S. ADENIRAN and Valeelat
OKEOLA
Abstract
Ribonucleotide reductase, an iron requiring enzyme necessary in the
production of deoxyribonucleotides required for replication in cell
division and proliferation is induced during the S phase of the cell
cycle. We have compared the trypanocidal properties of four antibiotics
that show bactericidal activities by destabilizing ribosome-mRNA
complex to inhibit protein synthesis. Tetracycline and oxytetracycline
that have iron chelating properties extended the lifespan of
trypanosome infected rats from 6 and 5 days of control to 15 and 12
days respectively while chloramphenicol and streptomycin that have no
iron chelating properties could not extend the lifespan of infected
rats. We confirm our earlier report that iron chelation plays a
prominent role in the tetracycline management of African
trypanosomosis.
Keywords
Tetracycline, iron chelation, T. brucei, growth inhibition
=A9 Copyright 2004 - Nigerian Society for Experimental Biology
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
| |
| outsor@citynet.net 2005-09-24, 2:08 pm |
| "Ribonucleotide reductase, an iron requiring enzyme necessary in the
production of deoxyribonucleotides required for replication in cell
division and proliferation is induced during the S phase of the cell
cycle. "
In other words, iron must be present for normal cell life and duplication,
without it we would soon die. Thank you for this.
| |
|
|
| outsor@citynet.net 2005-09-24, 2:08 pm |
| "So .. you WOULD iron supplement these .. poor .. 'anemic' .. malnourished
people .. with .. iron .."
Nope, malnutrition is not the cause of the disorder. I know what is but
don't want to spoil your fun on the search enjines trying to find it also.
The part of the abstract said iron is needed for normal cell growth,
nothing to do with the above and in direct contridiction to the round
peg/square hole reasoning you employ in posting these often contridicting
hole in foot creating abstracts.
..
| |
|
|
| outsor@citynet.net 2005-09-24, 2:08 pm |
| "I thought I'd let it pass the first time you spelled it wrong .."
But the important question is did you clean up after yourself after
passing it? Or are you contridicting yourself again?
|
| |
|
|