| ironjustice@aol.com 2005-09-24, 2:08 pm |
| Mol Cell Biochem. 2005 Sep;277(1-2):73-80. Related Articles, Links
A novel antioxidant agent caffeic acid phenethyl ester prevents
long-term mobile phone exposure-induced renal impairment in rat.
Ozguner F, Oktem F, Ayata A, Koyu A, Yilmaz HR.
Department of Physiology, School of Medicine, Suleyman Demirel
University, P. K. 13, Isparta, 32100, Turkey, drmfehmi@yahoo.com.
Caffeic acid phenethyl ester (CAPE), a flavonoid like compound, is one
of the major components of honeybee propolis. It has been used in folk
medicine for many years in Middle East countries. It was found to be a
potent free radical scavenger and antioxidant recently. The aim of this
study was to examine long-term applied 900 MHz emitting mobile
phone-induced oxidative stress that promotes production of reactive
oxygen species (ROS) and, was to investigate the role of CAPE on kidney
tissue against the possible electromagnetic radiation (EMR)-induced
renal impairment in rats. In particular, the ROS such as superoxide and
nitric oxide (NO) may contribute to the pathophysiology of EMR-induced
renal impairment. Malondialdehyde (MDA, an index of lipid peroxidation)
levels, urinary N-acetyl-beta-D: -glucosaminidase (NAG, a marker of
renal tubular injury) and nitric oxide (NO, an oxidant product) levels
were used as markers of oxidative stress-induced renal impairment and
the success of CAPE treatment. The activities of superoxide dismutase
(SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in renal
tissue were determined to evaluate the changes of antioxidant status.
The rats used in the study were randomly grouped (10 each) as follows:
i) Control group (without stress and EMR), ii) Sham-operated rats
stayed without exposure to EMR (exposure device off), iii) Rats exposed
to 900 MHz EMR (EMR group), and iv) A 900 MHz EMR exposed + CAPE
treated group (EMR + CAPE group). In the EMR exposed group, while
tissue MDA, NO levels and urinary NAG levels increased (p < 0.0001),
the activities of SOD, CAT, and GSH-Px in renal tissue were reduced (p
< 0.001). CAPE treatment reversed these effects as well (p < 0.0001, p
< 0.001 respectively). In conclusion, the increase in NO and MDA levels
of renal tissue, and in urinary NAG with the decrease in renal SOD,
CAT, GSH-Px activities demonstrate the role of oxidative mechanisms in
900 MHz mobile phone-induced renal tissue damage, and CAPE, via its
free radical scavenging and antioxidant properties, ameliorates
oxidative renal damage. These results strongly suggest that CAPE
exhibits a protective effect on mobile phone-induced and free radical
mediated oxidative renal impairment in rats.
PMID: 16132717 [PubMed - in process]
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