| ironjustice@aol.com 2005-07-09, 5:53 pm |
| 'Those' .. in the seat of power .. medical health professionals .. have
now ramped UP the RDA for iron .
In light of recent discoveries .. they have effectively .. signed a
death warrant for .. many .. ?
Wouldn't this article state .. contrary .. to INCREASED iron in our
food supply .. the reduction OF .. iron .. might be more .. productive
... ?
Especially in light of the upcoming .. epidemics of .. avian flu .. and
the .. like .. ?
<<snip>>
The management of dietary iron can therefore be influential in aiding
the outcome of this disease.
<<snip>>
Tuberculosis (Edinb). 2004;84(1-2):110-30. Related Articles, Links
Iron, mycobacteria and tuberculosis.
Ratledge C.
Department of Biological Sciences, university of Hull, Hull HU6 7RX,
UK. c.ratle...@biosci.hull.ac.uk
The role of iron in the growth and metabolism of M. tuberculosis and
other mycobacteria is discussed in relation to the acquisiton of iron
from host sources, such as transferrin, lactoferrin and ferritin, and
its subsequent assimilation and utilization by the bacteria. Key
components involved in the acquisition of iron (as ferric ion) and its
initial transport into the mycobacterial cell are extracellular iron
binding agents (siderophores) which, in pathogenic mycobacteria, are
the carboxymycobactins and, in saprophytic mycobacteria, are the
exochelins. In both cases, iron may be transferred to an
intra-envelope, short-term storage molecule, mycobactin. For transport
across the cell membrane, a reductase is used which converts
FeIII-mycobactin to the FeII form. The ferrous ion, possibly complexed
with salicylic acid, is then shuttled across the membrane either for
direct incorporation into various porphyrins and apoproteins or, for
storage of iron within the bacterial cytoplasm, bacterioferritin. The
overall process of iron acquisition and its utilization is under very
genetic tight control. The importance of iron in the virulence of
mycobacteria is discussed in relationship to the development of
tuberculosis. The management of dietary iron can therefore be
influential in aiding the outcome of this disease. The role of the old
anti-TB compound, p-aminosalicylate (PAS), is discussed in its action
as an inhibitor of iron assimilation, together with the prospects of
being able to synthesize further selective inhibitors of iron
metabolism that may be useful as future chemotherapeutic agents.
Publication Types:
Review
Review, Tutorial
PMID: 14670352
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Tom
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