| ironjustice@aol.com 2005-07-09, 5:53 pm |
| This would give some credence to the theory sickle cell is an iron
overload disease .. from .. BIRTH .. and the iron overload destroys
tocopherol .. and BOTH .. problems MUST be addressed AT .. birth.
<<snip>>
Conclusion: This study shows that short-term supplementation with
alpha-tocopherol may be beneficial to the paediatric sickle cell
sufferer.
<<snip>>
Niger Postgrad Med J. 2005 Jun;12(2):110-4. Related Articles, Links
Changes in Erythrocytes following Supplementation with alpha-Tocopherol
in Children Suffering from Sickle Cell Anaemia.
Jaja SI, Aigbe PE, Gbenebitse S, Temiye EO.
Department of Physiology, college of Medicine, university of Lagos,
P.M.B. 12003, Lagos. Nigeria.
Introduction: Low plasma vitamin E level in children with sickle cell
anaemia has been related to elevated level of irreversibly sickled
cells which has been implicated in the pathogenesis of painful crisis.
In adult patients supplementation with alpha-tocopherol has been shown
to reduce irreversibly sickled cell count. In-addition, vitamin E
supplementation increases resting forearm blood flow and reduces
forearm vascular resistance in adult sickle cell anaemia sufferers.
Aim: The aim of the study was to examine the effects of supplementation
with alpha-tocopherol on arterial blood pressure, some haematological
parameters and osmotic fragility in children suffering from sickle cell
anaemia. Methodology: The effects of supplementation with
alpha-tocopherol (100 mg. per day for 6 weeks) on packed cell volume
(PCV) haemoglobin concentration ([Hb]), mean corpuscular haemoglobin
concentration (MCHC), per cent foetal haemoglobin (% HbF), per cent
irreversibly sickled cells (% ISC), erythrocyte osmotic fragility and
blood pressure have been assessed in ten (10) children suffering from
sickle cell anaemia. Their ages ranged from 4.0 to 10.0 years. Results:
Supplementation with alpha-tocopherol significantly increased packed
cell volume (p< 0.001), haemoglobin concentration (p< 0.01) and per
cent foetal haemoglobin (p< 0.001), but significantly reduced mean
corpuscular haemoglobin concentration (p< 0.01) and per cent
irreversibly sickled cells (p< 0.001). alpha-Tocopherol also increased
the resistance of the cells to lysis. Supplementation with
alpha-tocopherol had little or no effect on arterial blood pressure
Conclusion: This study shows that short-term supplementation with
alpha-tocopherol may be beneficial to the paediatric sickle cell
sufferer. . Keywords: sickle cell anaemia, erythrocytes,
alpha-tocopherol..
PMID: 15997260 [PubMed - in process]
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