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Home > Archive > Pathology > July 2005 > Even minor increase of iron / hepatitis
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Even minor increase of iron / hepatitis
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| ironjustice@aol.com 2005-07-03, 12:33 pm |
| Blood Cells, Molecules, and Diseases
Volume 35, Issue 1 , July-August 2005, Pages 27-32
Including Workshop on Exosomes: Part II
doi:10.1016/j.bcmd.2005.03.007
Copyright =A9 2005 Elsevier Inc. All rights reserved.
Association between heterozygosity for HFE gene mutations and hepatitis
viruses in hepatocellular carcinoma
Anna Ludovica Fracanzania, Silvia Fargiona, , , Maria Antonietta
Stazib, Luca Valentia, Pietro Amorosoc, Elisabetta Carianid, Angelo
Sangiovannie, Maurizio Tommasinif, Angelo Rossinid, Cristina Bertellia,
Erika Fattaa, Valeria Patriarcab, Sonia Brescianinib and Tomaso
Stroffolinib
aDipartimento Medicina Interna, Ospedale Maggiore IRCCS, Via F Sforza
35, 20122 Milano, Italy
bLaboratorio di Epidemiologia e Biostatistica Istituto Superiore di
Sanit=E0, Roma, Italy
cVI Divisione A.O. Domenico Cotugno, Napoli, Italy
dU.S.D. di Eaptologia Spedali Civili, Brescia, Italy
eU.O Epatologia, Ospedale Maggiore IRCCS Universit=E0 di Milano, Italy
fDivisione Medicina, Istituto Clinico Humanitas, Rozzano, Italy
Received 7 October 2004. (Communicated by E. Beutler, M.D., 24 March
2005). Available online 13 May 2005.
Abstract
Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are
strong and independent risk factors for hepatocellular carcinoma (HCC)
development. Patients with hereditary hemochromatosis (HH) are
considered at risk of developing cancer. However, the interaction
between HFE gene mutations and hepatitis viruses for HCC development
has not been systematically searched for. To assess the interaction
between HFE gene mutations and exogenous risk factors in the risk of
HCC occurrence, a case-only approach, in which just a series of
patients is enrolled, was used. Three hundred three cirrhotic patients
(231 males, 72 females) from five liver units in different geographic
areas of Italy, who developed HCC during regular follow-up between
January 1999 and March 2003, and whose blood DNA was available, were
analyzed. In all subjects, hepatitis B surface antigen (HBsAg),
anti-HCV and HFE gene mutations were assayed; alcohol intake was
recorded by history. The interaction between HFE genotypes and
hepatitis viruses for HCC was estimated by multivariate analysis
adjusting for the confounding effect of alcohol intake, area of
residence and months of follow-up. Of the 303 HCC cases, 12 (4.0%) were
heterozygous for the C282Y mutation, 93 (30.7%) for the H63D, and 198
(65.3%) homozygous for the wild allele. Multivariate analysis showed
that C282Y heterozygous males were 3.8-fold (95% CI =3D 1.0-15.2) more
likely to be HBV positive and that H63D heterozygous females were
6=2E0-fold (95% CI =3D 1.2-113.8) more likely to be HCV positive than
wild type subjects. In conclusion, given the association between C282Y
mutation and HBV infection in male patients with HCC, a careful
evaluation and follow-up should be considered in the C282Y-positive
subjects with hepatitis B virus related liver disease. The interaction
between the H63D mutation and HCV, observed only in women, may reflect
a higher sensitivity to H63D-induced iron metabolism abnormalities and
a reduced antioxidant capability in the presence of an even minor
increase of iron which may occur as a consequence of the coexistence of
hepatitis C infection and heterozygosity for HH.
Keywords: HBV infection; HCV infection; HFE mutations; Hepatocellular
carcinoma
Grant: Financial support: Viral Hepatitis Project, Istituto Superiore
di Sanit=E0 (D.leg.vo 30/12/1992 n.502), COFIN 2002, FIRB 2001, FIRST
2002.
Corresponding author. Fax: +39 02 503 20296.
Blood Cells, Molecules, and Diseases
Volume 35, Issue 1 , July-August 2005, Pages 27-32
Including Workshop on Exosomes: Part II
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
| |
| outrider 2005-07-03, 12:33 pm |
|
Thank you Tom.
Zee
ironjustice@aol.com wrote:
> Blood Cells, Molecules, and Diseases
> Volume 35, Issue 1 , July-August 2005, Pages 27-32
> Including Workshop on Exosomes: Part II
> doi:10.1016/j.bcmd.2005.03.007
> Copyright =A9 2005 Elsevier Inc. All rights reserved.
>
> Association between heterozygosity for HFE gene mutations and hepatitis
> viruses in hepatocellular carcinoma
>
> Anna Ludovica Fracanzania, Silvia Fargiona, , , Maria Antonietta
> Stazib, Luca Valentia, Pietro Amorosoc, Elisabetta Carianid, Angelo
> Sangiovannie, Maurizio Tommasinif, Angelo Rossinid, Cristina Bertellia,
> Erika Fattaa, Valeria Patriarcab, Sonia Brescianinib and Tomaso
> Stroffolinib
>
> aDipartimento Medicina Interna, Ospedale Maggiore IRCCS, Via F Sforza
> 35, 20122 Milano, Italy
> bLaboratorio di Epidemiologia e Biostatistica Istituto Superiore di
> Sanit=E0, Roma, Italy
> cVI Divisione A.O. Domenico Cotugno, Napoli, Italy
> dU.S.D. di Eaptologia Spedali Civili, Brescia, Italy
> eU.O Epatologia, Ospedale Maggiore IRCCS Universit=E0 di Milano, Italy
> fDivisione Medicina, Istituto Clinico Humanitas, Rozzano, Italy
>
> Received 7 October 2004. (Communicated by E. Beutler, M.D., 24 March
> 2005). Available online 13 May 2005.
>
> Abstract
> Hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are
> strong and independent risk factors for hepatocellular carcinoma (HCC)
> development. Patients with hereditary hemochromatosis (HH) are
> considered at risk of developing cancer. However, the interaction
> between HFE gene mutations and hepatitis viruses for HCC development
> has not been systematically searched for. To assess the interaction
> between HFE gene mutations and exogenous risk factors in the risk of
> HCC occurrence, a case-only approach, in which just a series of
> patients is enrolled, was used. Three hundred three cirrhotic patients
> (231 males, 72 females) from five liver units in different geographic
> areas of Italy, who developed HCC during regular follow-up between
> January 1999 and March 2003, and whose blood DNA was available, were
> analyzed. In all subjects, hepatitis B surface antigen (HBsAg),
> anti-HCV and HFE gene mutations were assayed; alcohol intake was
> recorded by history. The interaction between HFE genotypes and
> hepatitis viruses for HCC was estimated by multivariate analysis
> adjusting for the confounding effect of alcohol intake, area of
> residence and months of follow-up. Of the 303 HCC cases, 12 (4.0%) were
> heterozygous for the C282Y mutation, 93 (30.7%) for the H63D, and 198
> (65.3%) homozygous for the wild allele. Multivariate analysis showed
> that C282Y heterozygous males were 3.8-fold (95% CI =3D 1.0-15.2) more
> likely to be HBV positive and that H63D heterozygous females were
> 6.0-fold (95% CI =3D 1.2-113.8) more likely to be HCV positive than
> wild type subjects. In conclusion, given the association between C282Y
> mutation and HBV infection in male patients with HCC, a careful
> evaluation and follow-up should be considered in the C282Y-positive
> subjects with hepatitis B virus related liver disease. The interaction
> between the H63D mutation and HCV, observed only in women, may reflect
> a higher sensitivity to H63D-induced iron metabolism abnormalities and
> a reduced antioxidant capability in the presence of an even minor
> increase of iron which may occur as a consequence of the coexistence of
> hepatitis C infection and heterozygosity for HH.
>
> Keywords: HBV infection; HCV infection; HFE mutations; Hepatocellular
> carcinoma
>
>
> Grant: Financial support: Viral Hepatitis Project, Istituto Superiore
> di Sanit=E0 (D.leg.vo 30/12/1992 n.502), COFIN 2002, FIRB 2001, FIRST
> 2002.
> Corresponding author. Fax: +39 02 503 20296.
>
>
> Blood Cells, Molecules, and Diseases
> Volume 35, Issue 1 , July-August 2005, Pages 27-32
> Including Workshop on Exosomes: Part II
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!
> http://jesuswasavegetarian.7h.com
> Man Is A Herbivore!
> http://pages.ivillage.com/ironjustice/manisaherbivore
> DEAD PEOPLE WALKING
> http://pages.ivillage.com/ironjustice/deadpeoplewalking
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