| ironjustice@aol.com 2005-07-03, 12:33 pm |
| Below is a snip from a recent article.
>From the Department of Pathology, Immunology, and Laboratory
Medicine, university of Florida college of Medicine.
Submitted for publication July 8, 2004; accepted for publication
October 7, 2004.
Reprint requests: Jerome L. Sullivan, MD, PhD, 315 Salvador
Square, Winter Park, FL 32789; e-mail: jlsullivan@pol.net.
J Lab Clin Med 2004;144:280-4.
0022-2143/$ - see front matter
=A9 2004 Elsevier Inc. All rights reserved.
doi:10.1016/j.lab.2004.10.006
280
REVIEW ARTICLE
Is stored iron safe?
JEROME L. SULLIVAN
GAINESVILLE, FLORIDA
Abbreviations: 80HdG 8-hydroxydeoxyguanosine; ROS reactive oxygen
species
It's not what we don't know about nutrition that hurts us, it is
what we know for sure that turns out to be dead wrong.
-attributed to Victor Herbert, MD, JD
Studies of oxidative DNA damage and iron merit
mention in this context. 8OHdG has been widely used
as a marker of oxidative DNA damage; in insects, its
levels have been found to be inversely associated with
life expectancy.45 In men and women, the urinary con-centration
of 8OHdG was recently shown to increase
with the serum ferritin level (Fig 1).46 Dependence of
8OHdG on serum ferritin is seen within the range of
conventionally normal ferritin values. The data are
compatible with the conclusion that acquisition of even
very small amounts of stored iron in human beings
enhances resting levels of oxidative DNA damage. Two
studies in rodents have found that iron deprivation is
associated with much lower 8OHdG levels and dimin-ished
pathologic endpoints.26,36 The findings of these
iron-deprivation experiments suggest that the increase
in 8OHdG with serum ferritin in the human data of
Nakano et al 46 is not a spurious association but instead
is caused by the acquisition of stored iron. Taken to-gether,
these findings challenge the traditional notion
that stored iron is safe and support the possibility that
iron restriction increases longevity in mammals.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
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DEAD PEOPLE WALKING
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