| ironjustice@aol.com 2005-06-22, 10:52 pm |
| Am J Trop Med Hyg. 2005 Jun;72(6):660-5. Related Articles, Links
Attenuation of cytoadherence of Plasmodium falciparum to microvascular
endothelium under flow by hemodilution.
Flatt C, Mitchell S, Yipp B, Looareesuwan S, Ho M.
Department of Microbiology and Infectious Diseases and Immunology
Research Group, university of Calgary, Calgary, Alberta, Canada;
Hospital for Tropical Diseases, Faculty of Tropical Medicine, Mahidol
University, Bangkok, Thailand.
The cytoadherence of Plasmodium falciparum-infected erythrocytes
(IRBCs) to endothelium is mediated by adhesion molecules within the
physical constraints of a viscous fluid containing mostly erythrocytes.
The volume fraction of erythrocytes (hematocrit) and their physical
properties, such as deformability, are important properties of blood
that affect cell recruitment to the vascular wall. In the present
study, we examined the effect of hematocrit on IRBC rolling and
adhesion on human microvascular endothelial cells in a flow chamber
system in vitro. We found hematocrit to be a major determinant of
IRBC/endothelial cell interactions. There was a 5-fold and 12-fold
increase in IRBC rolling and adhesion, respectively, when hematocrit
increased from 10% to 30%, as a result of changes in shear rate.
Similar effects were seen in the presence of less deformable
erythrocytes, serum proteins, and on endothelium stimulated with tumor
necrosis factor-alpha. The results indicate that hemorheologic
variations are an important determinant of the degree of cytoadherence.
PMID: 15964947 [PubMed - in process]
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