| ironjustice@aol.com 2005-06-18, 6:22 pm |
| Alcohol Clin Exp Res. 1999 May;23(5):944-9. Related Articles, Links
Prevention and treatment of liver fibrosis based on pathogenesis.
Lieber CS.
Alcohol Research and Treatment Center, Bronx Veterans Affairs Medical
Center and Mount Sinai School of Medicine, New York 10468, USA.
liebercs@aol.com
Multiple agents have been proposed for the prevention and treatment of
fibrosis. S-adenosylmethionine was reported to oppose CCl4-induced
fibrosis in the rat, to attenuate the consequences of the
ethanol-induced oxidative stress, and to decrease mortality in
cirrhotics. Anti-inflammatory medications and agents that interfere
with collagen synthesis, such as inhibitors of prolyl-4-hydroxylase and
antioxidants, are also being tested. In nonhuman primates,
polyenylphosphatidylcholine (PPC), extracted from soybeans, protected
against alcohol-induced fibrosis and cirrhosis and prevented the
associated hepatic phosphatidylcholine (PC) depletion by increasing
18:2 containing PC species; it also attenuated the transformation of
stellate cells into collagen-producing transitional cells. Furthermore,
it increased collagen breakdown, as shown in cultured stellate cells
enriched with PPC or pure dilinoleoyl PC, the main PC species present
in the extract. Because PPC and dilinoleoyl PC promote the breakdown of
collagen, there is reasonable hope that this treatment may be useful
for the management of fibrosis of alcoholic, as well as nonalcoholic,
etiologies and that it may affect not only the progression of the
disease, but may also reverse pre-existing fibrosis, as demonstrated
for CCl4-induced cirrhosis in the rat and as presently tested in an
ongoing clinical trial.
Publication Types:
Review
Review, Tutorial
PMID: 10371420 [PubMed - indexed for MEDLINE]
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