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Home > Archive > Pathology > June 2005 > Iron deposition / ambulatory impairment in multiple sclerosis
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Iron deposition / ambulatory impairment in multiple sclerosis
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| ironjustice@aol.com 2005-06-06, 8:56 am |
| http://tinyurl.com/d535u
<<snip>>
This study adds more weight to the notion that T2 hypointensity is a
clinically relevant marker of tissue damage in MS.
<<snip>>
Journal of the Neurological Sciences
Article in Press, Corrected Proof - Note to users
doi:10.1016/j.jns.2005.02.009
Copyright =A9 2005 Elsevier B.V. All rights reserved.
MRI T2 hypointensity of the dentate nucleus is related to ambulatory
impairment in multiple sclerosis
C=2EW. Tjoaa, R.H.B. Benedicta, b, c, B. Weinstock-Guttmana, A.J.
Fabianoa and R. Bakshid, ,
aDepartment of Neurology, university at Buffalo, State university of
New York, Buffalo, NY, USA
bDepartment of Psychiatry university at Buffalo, State university of
New York, Buffalo, NY, USA
cDepartment of Psychology, university at Buffalo, State university of
New York, Buffalo, NY, USA
dDepartments of Neurology and Radiology, Center for Neurological
Imaging, Partners Multiple Sclerosis Center, Brigham & Women's
Hospital, Harvard Medical School, 77 Avenue Louis Pasteur-HIM 730
Boston, MA 02115, USA
Received 29 October 2004; revised 24 January 2005; accepted 18
February 2005. Available online 22 April 2005.
Abstract
Objectives
MRI T2 hypointensity in multiple sclerosis (MS) gray matter, suggesting
iron deposition, is associated with physical disability, disease
course, lesion load, and brain atrophy. Ambulatory dysfunction limits
quality of life; however correlation with conventional MRI remains
poor.
Methods
Normalized intensity on T2-weighted images was obtained in the basal
ganglia, thalamus, red nucleus, and dentate nucleus in 47 MS patients
and 15 healthy controls. Brain T1-hypointense and FLAIR-hyperintense
lesion volume, third ventricle width, brain parenchymal fraction and
timed 25 foot walk (T25FW) were measured in the MS group.
Results
T2 hypointensity was present throughout gray matter in MS vs. controls
(all p < 0.01). Dentate T2 hypointensity was the only MRI variable
significantly correlated with T25FW (Pearson r =3D -0.355, p =3D 0.007) and
was also the best MRI correlate of physical disability (EDSS) score in
regression modeling (r =3D -0.463, R2 =3D 0.223, p =3D 0.004).
Conclusions
T2 hypointensity is present in subcortical gray matter nuclei in
patients with MS vs. normal controls. Dentate nucleus T2 hypointensity
is independently related to ambulatory impairment and disability,
accounting for more variance than conventional lesion and atrophy
measures. This study adds more weight to the notion that T2
hypointensity is a clinically relevant marker of tissue damage in MS.
Keywords: MRI; Multiple sclerosis; Iron; Gray matter; T2 shortening;
Ambulation
Corresponding author. Tel.: +1 617 732 8600; fax: +1 617 525 5223.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.=ADcom
Man Is A Herbivore!
http://pages.ivillage.com/iron=ADju...manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/iron=ADju...adpeoplewalking
| |
| Jim Carter 2005-06-06, 5:54 pm |
| On 6 Jun 2005 00:12:22 -0700, "ironjustice@aol.com"
<ironjustice@aol.com> wrote in alt.support.mult-sclerosis:
><<snip>>
>This study adds more weight to the notion that T2 hypointensity is a
>clinically relevant marker of tissue damage in MS.
><<snip>>
Do you have any idea how many times you have posted this same
piece of crap that has never been supported by another
institution or researcher? You steadfastly refuse to answer
questions put to you about it and after all this time Bakshi is
beginning to back off and now say that his work only "suggests".
His earlier statements expressed far more certainty. See how
many times you have run off and hid with your tail between your
legs, just follow the link below.
http://tinyurl.com/cwz9t
--
Gardening Zones
Canada Zone 5a
United States Zone 3a
Near Ottawa, Ontario
| |
| ironjustice@aol.com 2005-06-06, 10:52 pm |
| >Do you have any idea how many times you have posted this same
piece of crap <
Available online 22 April 2005.
Jeez .. the date says I couldn't have posted it .. before .. what? ..
April 22 , 2005 ..?
Maybe .. I .. just .. missed .. it ..
Who fkg .. cares whether I missed it or .. not ..
Read .. my .. lips .. jrkff ..
STAY .. off .. my .. threads ..
You have a .. problem .. with .. ME ..
So .. keep .. it .. to .. your .. fkg .. self ..
Too hard for ya .. ?
Must .. be ..
While I'm here should I post how .. minocycline .. is .. an iron
chelator .. ?
Jeez .. I just .. did ..
Heh .. heh ..
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.=ADcom
Man Is A Herbivore!
http://pages.ivillage.com/iron=ADju...manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/iron=ADju...adpeoplewalking
| |
| John Husvar 2005-06-07, 8:54 am |
| In article <sch9a1p81gm06av463t01m9lfbugb2reun@4ax.com>,
Jim Carter <spamfree@sentex.ca> wrote:
> On 6 Jun 2005 00:12:22 -0700, "ironjustice@aol.com"
> <ironjustice@aol.com> wrote in alt.support.mult-sclerosis:
>
>
> Do you have any idea how many times you have posted this same
> piece of crap that has never been supported by another
> institution or researcher? You steadfastly refuse to answer
> questions put to you about it and after all this time Bakshi is
> beginning to back off and now say that his work only "suggests".
> His earlier statements expressed far more certainty. See how
> many times you have run off and hid with your tail between your
> legs, just follow the link below.
>
I imagine he's back with his out-of-context Bible verses and
inapplicable "research" because his DEERly beloved Wife of His Youth is
as ticked at him as we are.
Yes, Tom, you XXX, I did read it all: I just wasn't about to play _your_
game.
Bed, Twerp!
Tk yp fkg crp elswhr.
Who doesn't love ya? Your DEERly beloved.
I'll be looking for her come Deer Season.
Have a nice eternity -- one might hope in oblivion.
Bye.
Time for entry number three in my killfile. Sad, because there's the
barest possibility some little piece of his Nobel Prize project just
might apply. If only he had learned elementary politeness in grammar
school.
| |
| Twittering One 2005-06-07, 11:51 am |
| "... He'll pace allright but then look carefully
at how, reaching the edge, he turns around...
.... that quick step
revolving on the one hind leg, bringing the other down just as
the swivel ends, then giving over all the weight
to one front paw, onto each pad distinctly it would
seem, then onto number four and he's
around headed the other way
again."
~ Jorie Graham,
>From "The Sense of an Ending,"
>From "Erosion"
*
"... better off just
Going for The Blinking Lynx,
An adept solution, if the Lynx thinks, too.
If not, too primitive yet, too innocent, tme thinks
To meet The Minx."
~ Frank Lodge
"A Crosse, X,
Marks the spot, one the distal, an S, the proximal, a U."
~ Kenneth
"And, moreover, alas, ever after, some Mulberry
Wine from Muldavia, some cherry picking
For our homework,
And more than unlikely
More Graham snackin' crackers later,
Smore mores too ..."
~ Keenkix
*
Darkness
Visible ~
"No woe for me Twittering
One
'No light, but rather darkness visible.'
Look carefully.
It is an oxymoron which isn't so.
... 'Illumination' as revealed by differing shades of
darkness."
~ Raving
"Chiaroscuro, or
Sfumato?"
~ Folly
"O, I know ~ Ask Leonardo ~ ! Heck,
Yeah ~ !"
~ Twittering
"Heck, yeah ~ !
Leonardo knows everything ~ !"
~ Folly
"Bed, Twerp!
Tk yp fkg crp elswhr.
Who doesn't love ya?
Your DEERly beloved.
I'll be looking for her come Deer Season.
Have a nice eternity ~ One might hope in oblivion."
~ Husvar
"Okey dokey."
~ Twittering
| |
| Jim Carter 2005-06-07, 5:54 pm |
| On 6 Jun 2005 20:39:33 -0700, "ironjustice@aol.com"
<ironjustice@aol.com> wrote in alt.support.mult-sclerosis:
>piece of crap <
>
>Available online 22 April 2005.
>
>Jeez .. the date says I couldn't have posted it .. before .. what? ..
>April 22 , 2005 ..?
>
>Maybe .. I .. just .. missed .. it ..
>
>Who fkg .. cares whether I missed it or .. not ..
>
You have been posting Bakri's article every year since the year
2000; he just re-writes it. Can you not remember these things?
I guess you have cognitive problems. Iron deficiency can cause
that, you know.
>Read .. my .. lips .. jrkff ..
>
>STAY .. off .. my .. threads ..
>
No. In fact I might post the other warning about you. You know
the one.
>You have a .. problem .. with .. ME ..
>
>So .. keep .. it .. to .. your .. fkg .. self ..
>
I do not have a problem with you Tommy, you have a problem with
yourself. If you were smart, you would run, not walk, to the
nearest psychiatrist's office. But everyone knows you are not
smart so what word is the opposite of smart?
>Too hard for ya .. ?
>
>Must .. be ..
>
One day the folks in the clean white suits will come for you. In
the meantime, I find you a good target for my frustrations.
Nothing more.
>While I'm here should I post how .. minocycline .. is .. an iron
>chelator .. ?
>
>Jeez .. I just .. did ..
>
Why would you want to remove one of the best antioxidants in
existence?
>Heh .. heh ..
>
Heh .. heh .. right back atcha, stunned one.
You are seeing this message because Tom Hennessy
aka ironjustice@aol.com has posted a message. If you are new to
these
groups then please understand that he appears to get
his thrills from the misfortunes of other people,
evidenced by his comments to the victims of forest
fires, the passing of members of these newsgroups and
his presence on all support newsgroups rather than the more
appropriate sci.med.* hierarchy.
In keeping with his personality, Tommy believes
discussions in these groups are conducted by
using off-colour language and name calling
that would make a rattlesnake spew. This personality
trait is shown here:
http://flyembie.notlong.com
He seems to believe that whoever swears loudest and
longest is the winner.
In his mind, Hennessy believes he is a great
researcher who has won a Nobel Prize. In fact, he
merely copies medical material from the web and
pastes it to usenet, proudly calling this his research.
There was a time when people like Tommy were
institutionalized, now they are allowed to run for
public office and post to usenet. He is a fine
example why a mental health unit should not
obtain an internet account.
Previous addresses include watchman@nucleus.com,
thennessy@telus.net, darreltaylor911@hotmail.com.
--
Gardening Zones
Canada Zone 5a
United States Zone 3a
Near Ottawa, Ontario
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