| ironjustice@aol.com 2005-06-05, 8:52 am |
| Eur J Neurosci. 2005 May;21(9):2521-2528. Related Articles, Links
Recognition memory impairment and brain oxidative stress induced by
postnatal iron administration.
de Lima MN, Polydoro M, Laranja DC, Bonatto F, Bromberg E, Moreira JC,
Dal-Pizzol F, Schroder N.
Programa de Pos-Graduacao em Gerontologia Biomedica, Instituto de
Geriatria e Gerontologia and Laboratorio de Memoria e Neurodegeneracao,
Departamento de Ciencias Fisiologicas, Faculdade de Biociencias,
Pontificia Universidade Catolica do Rio Grande do Sul, 90619-900 Porto
Alegre, RS, Brazil.
Abstract Iron accumulation in the brain has been implicated in the
pathogenesis of neurodegenerative disorders. It is known that iron
catalyses the formation of highly reactive hydroxyl radicals. Recent
studies have implicated oxidative damage in memory deficits in rats and
humans. The purpose of the present study was to investigate the
long-term effects of iron treatment in four different phases of the
neonatal period on recognition memory in rats. Additionally, parameters
of oxidative stress in cerebral regions related to memory formation
were evaluated. Male Wistar rats received vehicle or 10.0 mg/kg of
Fe(2+) orally at postnatal days 5-7, 12-14, 19-21 or 30-32. Animals
given iron at any phase of the neonatal period showed impairments in
long-term retention of object recognition memory, although only the
group given iron from postnatal days 12-14 showed a complete memory
blockade. Iron treatment induced oxidative damage in the brain as
assessed by the thiobarbituric acid reactive species assay. Moreover,
iron administration increased superoxide production in submitochondrial
particles, suggesting impaired mitochondrial function; and there was an
increase in superoxide dismutase activity in brain regions susceptible
to iron administration. The results show that iron load in the early
stages of life induces cognitive impairment possibly by inducing
oxidative damage in the brain. These findings are consistent with the
view that oxidative stress may be related to the cognitive decline
observed in normal ageing.
PMID: 15932609 [PubMed - as supplied by publisher]
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