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Home > Archive > Pathology > June 2005 > HIV viral load remained at undetectable levels
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HIV viral load remained at undetectable levels
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| ironjustice@aol.com 2005-06-01, 9:02 am |
| Braz J Infect Dis. 2000 Aug;4(4):204-7. Related Articles, Links
Polycythemia vera in a patient with the human immunodeficiency virus: a
case report.
Sassaki MG, Souza CA, Siciliano RF, Leite AG, Padilha SL.
Federal university of Parana, Curitiba, Brazil.
It has been suggested that HIV plays a role in the generation of
myeloproliferative disorders, including polycythemia vera (PV). Seven
cases of polycythemia in HIV patients have been described in the
literature, but only 3 of these met criteria for determining a primary
origin (vera) of polycythemia. We report a case of PV in a patient
infected with HIV. A 45 year old non-smoking homosexual male presented
with 15.7 g/dl hemoglobin in 1991, and was diagnosed with HIV. After 7
years, he presented with plethora, splenomegaly, an erythrocyte mass of
71 ml/kg, and an oxygen saturation of 93.9% (the latter three
constituting the major criteria for the diagnosis of PV). Erythrocytes
7.35 x 10(6)/ml hemoglobin, 21.4 g/dl, hematocrit 63%, leukocytes
12,400, erythropoietin < 5 nmoll/ml. These values are all compatible
with a diagnosis of PV. The CD4 count was 321 cells/mm(3) and HIV viral
load was undetectable. The patient was initially treated with
zidovudine. He was then treated with didanosine, lamivudine, and
saquinavir, but all of them failed to slow the increase in erythrocyte
levels. After a diagnosis of PV, he was treated with hydroxyurea and
phlebotomy, which normalized the hemogram. CD4 count rose to 474
cells/mm(3) and HIV viral load remained at undetectable levels. The
patient remains in stable condition with combination treatment after 1
year. We suggest that this is a case of HIV infection which may have
led to the emergence of polycythemia vera. Treatment of the HIV did not
prevent the appearance of the myeloproliferative disorder.
Publication Types:
Case Reports
PMID: 11184768 [PubMed - indexed for MEDLINE]
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Tom
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| GMCarter 2005-06-01, 9:02 am |
| On 31 May 2005 22:09:04 -0700, "ironjustice@aol.com"
<ironjustice@aol.com> wrote:
>Braz J Infect Dis. 2000 Aug;4(4):204-7. Related Articles, Links
>
>
>Polycythemia vera in a patient with the human immunodeficiency virus: a
>case report.
I wonder if he was using anabolic steroids?
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| Manky Badger 2005-06-01, 9:02 am |
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<ironjustice@aol.com> wrote in message
news:1117602544.770042.75410@g49g2000cwa.googlegroups.com...
> Braz J Infect Dis. 2000 Aug;4(4):204-7. Related Articles, Links
>
>
> Polycythemia vera in a patient with the human immunodeficiency virus: a
> case report.
Someone HIV positive developed polycythaemia.
The implication is that someone without polycythaemia (i.e. someone with
LOWER iron stores) wouldn't ?
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| PeterB 2005-06-01, 5:52 pm |
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Manky Badger wrote:
> <ironjustice@aol.com> wrote in message
> news:1117602544.770042.75410@g49g2000cwa.googlegroups.com...
>
> Someone HIV positive developed polycythaemia.
> The implication is that someone without polycythaemia (i.e. someone with
> LOWER iron stores) wouldn't ?
Tom can makes these studies sing.
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| montygram 2005-06-01, 5:52 pm |
| "...it has been suggested..." has largely replaced real science these
days. Exaclty what they are saying is anyone's guess. One patient's
history is not helpful in this context, and rarely is helpful in any
scientific/medical context (assuming the researchers know what they're
doing). We have here all kinds of assumptions about what it happening,
then the best explanation, excess oxidative stress, in not mentioned.
One or more of the "life saving" drugs he was giving is probably
killing the poor guy, unless they took him off it in time.
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| David Wright 2005-06-01, 10:52 pm |
| In article <1117648168.347508.163760@f14g2000cwb.googlegroups.com>,
PeterB <pkm@mytrashmail.com> wrote:
>
>
>Manky Badger wrote:
>
>Tom can makes these studies sing.
Badly off-key.
-- David Wright :: alphabeta at prodigy.net
These are my opinions only, but they're almost always correct.
"I don't need someone to tell me that George W. Bush is a
deceitful, corrupt, clever and destructive man--that's pretty
clear on the face of it." -- Garrison Keillor
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