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Author Questions about TB/Latencies?
lordshiva5753@rediffmail.com

2005-05-31, 8:53 am

Hi,

I have following thoughts/confusions/questions:-

1. Suppose a person is exposed to TB bacterias & gets some acute
reactions from these but didn't get it as full active stage. So he
aquires latent TB infections with out any symptoms. I think it is due
to inability of immunity to handle all the bacterias on its exposure at
that time. Our defence system then opt for 2nd option--arrest/encapsule
these bacterias as latent stage to stop their multiplication & spread
or starve these in capsule by arresting or wait for the right
oppurtunity by improving the immunity/defence power to handle or kill
them. Is it right?

Now suppose that person got his immunity/defence power suitably
improved after some time which can then become capable to handle those
hidden/dormant or encapsuled bacterias in latency OR weakens his
immunity.

What will happen? On improved immunity--will those bacterias be
resurfaced/directly exposed to immune agents to kill the bacterias as a
"direction towards cure" but presenting an apparent impression of
active stage OR not? On weakened immunity--will these infecting agents
be resurfaced, multiply & spread as a "direction towards spread of
disease" OR not? We can also think similarily for cancer.

In short; can an impression of active stage/spread after a
latency/tumor formation be a direction towards cure on improved
immunity AND a direction of increase the infection/disease on weakening
the immunity/defence power?

2. Whether excess/low gastric acid can effect the effectiveness of TB
durgs? Suppose a person under this TB tratment, if lives in a place
with hard water/alkaline water supply OR take other foods which can
raise his gastric pH, can experiance lesser effects of TB medicines or
not? In short, I want to know whether imbalances in digetive pH can
effect the effectiveness/absorption of TB medicines or not?

3. Does immune defence system withhold iron or other nutrition to
starve those bacterials in their latent stage (also cancer cells in
their tumor stage)

4. Can low imbalances in digestive pHs also encourage intestinal mucus
blocks resulting into low medicines absorption?

I shall be thankful if you can reply/discuss these questions.

Kumar

2005-06-01, 9:02 am

"M. tuberculosis was the most restricted in growth at pH 6.0, and all
of this growth required elevated levels of Mg2+...These results
demonstrate that M. tuberculosis is unique among the mycobacteria in
its extreme sensitivity to acid and indicate that M. tuberculosis must
acquire sufficient Mg2+ in order to grow in a mildly acidic environment

such as within the phagosome of macrophages.
http://iai.asm.org/cgi/content/abst...pe2=tf_ipsecsha "
Does it indicate awnser to my sceond question?

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