| ironjustice@aol.com 2005-05-30, 9:00 am |
| Behav Brain Res. 2004 Oct 5;154(2):321-9. Related Articles, Links
Stress-induced behaviour in juvenile rats: effects of neonatal
asphyxia, body temperature and chelation of iron.
Rogalska J, Caputa M, Wentowska K, Nowakowska A.
Department of Animal Physiology, Institute of General and Molecular
Biology, N. Copernicus University, ul. Gagarina 9, 87-100 Torun,
Poland. rogal@biol.uni.torun.pl
Newborn mammals, showing reduced normal body temperature, might be
protected against iron-mediated, delayed neurotoxicity of perinatal
asphyxia. Therefore, we investigated the effects of (1) neonatal body
temperature and neonatal critical anoxia as well as (2) postanoxic
chelation of iron with deferoxamine, on open-field stress-induced
behaviour in juvenile rats. The third aim of this study was to compare
(after the above-mentioned treatments) circadian changes in spontaneous
motor activity and body temperature in juvenile rats permanently
protected from any stress. Neonatal anoxia at body temperature adjusted
(both during anoxia and 2 h reoxygenation) to a level typical of
healthy (37 degrees C) or febrile (39 degrees C) adults led to the
stress-induced hyperactivity in juvenile (5-45 days old) rats. Both
normal neonatal body temperature of 33 degrees C and chelation of iron
prevented the hyperactivity in rats. Neither neonatal body temperature
nor neonatal anoxia affected spontaneous motor activity or body
temperature of juvenile rats, recorded in their home-cages with
implantable transmitters. Circadian rhythmicity was also undisturbed.
Presented data support the hypothesis that physiologically reduced
neonatal body temperature can provide a protection against
iron-mediated postanoxic disturbances of behavioural stress responses
in juvenile rats.
PMID: 15313019 [PubMed - indexed for MEDLINE]
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