| ironjustice@aol.com 2005-04-13, 4:40 pm |
| Hepatogastroenterology. 2005 Mar-Apr;52(62):563-6. Related Articles,
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Additional effect of low iron diet on iron reduction therapy by
phlebotomy for chronic hepatitis C.
Kimura F, Hayashi H, Yano M, Yoshioka K, Matsumura T, Fukuda T, Shigeto
N, Yamahara S, Koushi F, Mishima Y, Yoshino T, Tanimoto M, Kimura I.
Department of Internal Medicine, Tamano-Municipal Hospital, Tamano
City, Okayama, Japan. f-kimura@po1.oninet.ne.jp
BACKGROUND/AIMS: Iron-induced oxidative stress plays an important role
in the pathogenesis of chronic hepatitis C. Both phlebotomy for
removing body iron stores and low iron diet for minimizing portal iron
supply to the liver have been shown to improve serum transaminase
levels in patients with the disease. However, the cooperative effects
of phlebotomy and low iron diet have not yet been elucidated in detail.
METHODOLOGY: A pilot study was undertaken to investigate whether a low
iron diet could improve the efficacy of phlebotomy in iron reduction
therapy. Of 21 patients diagnosed with chronic hepatitis C, 10 patients
were treated with phlebotomy alone (group A) while 11 patients were
treated with a low iron plus phlebotomy (group B). Phlebotomy was
repeated biweekly until serum ferritin levels reached 10 ng/mL in both
A and B groups. In addition, a low iron diet (iron intake of 8 mg/day
or less) was recommended for group B, followed by estimation of iron
intake from daily diet records. RESULTS: Serum alanine aminotransferase
levels were significantly improved from 106+/-30 to 68+/-22 IU/L
(p<0.005, paired t-test) in group A and from 100+/-33 to 46+/-10 IU/L
(p<0.002, paired t-test) in group B. The enzyme levels after treatment
were significantly higher in group A (p<0.02, non-paired t-test), which
showed a higher upward distribution of the enzyme activity. The
estimated dietary iron intake in group B was reduced from 17.6+/-6.1 to
8.2+/-3.7 mg/day. CONCLUSIONS: These findings suggest that phlebotomy
alone does not completely remove iron-induced oxidative stress and a
low iron diet induces an additional effect in iron reduction therapy
for chronic hepatitis C.
PMID: 15816478 [PubMed - in process]
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