| ironjustice@aol.com 2005-04-06, 8:47 am |
| Free Radic Biol Med. 2005 May 1;38(9):1206-11. Related Articles, Links
The iron chelator desferrioxamine inhibits atherosclerotic lesion
development and decreases lesion iron concentrations in the
cholesterol-fed rabbit.
Minqin R, Rajendran R, Pan N, Kwong-Huat Tan B, Ong WY, Watt F,
Halliwell B.
Centre for Ion Beam Applications, Department of Physics, National
University of Singapore, Singapore 117597.
Several epidemiological studies have suggested that increased iron
stores are associated with increased atherosclerotic events. In order
to test the hypothesis that decreasing the vascular level of iron slows
lesion growth, we examined the effects of the iron chelator Desferal
(72 mg/kg/day, 5 days/week) on atherosclerosis and lesion iron content
in cholesterol-fed New Zealand White rabbits. Rabbits were fed with a
1% w/w cholesterol diet for either 8 weeks (and for the last 5 weeks
injected daily with Desferal) or 12 weeks (and for the last 9 weeks
injected with Desferal). Controls were injected with saline. A
significant reduction in average lesion area (p = 0.038) was observed
in the 12-week treated animals compared with the 12-week controls. The
average lesion iron level of the 12-week treated animals (58 ppm dry
wt) was also significantly lower (p = 0.030) than in 12-week control
animals (95 ppm dry wt), as measured using nuclear microscopy with the
combination of scanning transmission ion microscopy, Rutherford
back-scattering spectroscopy, and particle-induced X-ray emission. No
reduction in lesion area or iron content was observed in the 8-week
treated animals compared with controls, and no change in lesion zinc
concentration was observed for either group. Our data strengthen the
concept that iron contributes to the early stages of the development of
atherosclerosis.
PMID: 15808418 [PubMed - in process]
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