| shorty8649@duskmail.com 2005-03-23, 5:38 pm |
|
ironjustice@aol.com wrote:
> FEMS Immunol Med Microbiol. 2005 Mar 1;43(3):325-30. Related Articles,
> Links
> Iron and infection: the heart of the matter.
> Bullen JJ, Rogers HJ, Spalding PB, Ward CG.
> Former Member of The National Institute for Medical Research, Mill
> Hill, London; Department of Surgery, School of Medicine, university of
> Miami, PO Box 016310, Miami FL 33101, USA.
> Bacterial resistance to antibiotics is a major threat to clinical
> medicine. However, natural resistance to bacterial infection, which
> does not depend on antibiotics, is a powerful protective mechanism
> common to all mankind. The availability of iron is the heart of the
> matter and the successful functioning of these antibacterial systems
> depends entirely upon an extremely low level of free ionic iron
> (10(-18) M) in normal tissue fluids. This in turn depends on
> well-oxygenated tissues where the oxidation-reduction potential (Eh)
> and pH control the binding of iron by unsaturated transferrin and
> lactoferrin. Bacterial virulence is greatly enhanced by freely
> available iron, such as that in fully-saturated transferrin or free
> haemoglobin. Following trauma a fall in tissue Eh and pH due to
> ischaemia, plus the reducing powers of bacteria, can make iron in
> transferrin freely available and abolish the bactericidal properties of
> tissue fluids with disastrous results for the host. Hyperbaric oxygen
> is a possible therapeutic measure that could restore normal
> bactericidal systems in infected tissues by raising the Eh and pH.
> PMID: 15708305 [PubMed - in process]
> --------------------------------------------------------------------------------
> Who loves ya.
> Tom
> Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
> Man Is A Herbivore!
> http://pages.ivillage.com/ironjustice/manisaherbivore
> DEAD PEOPLE WALKING
> http://pages.ivillage.com/ironjustice/deadpeoplewalking
Great!
shorty8649@duskmail.com
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