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Home > Archive > Pathology > March 2005 > iron chelators / infection / therapeutic or preventive agents
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iron chelators / infection / therapeutic or preventive agents
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| ironjustice@aol.com 2005-03-23, 5:37 pm |
| J Microbiol. 2005 Feb;43(1):54-61. Related Articles, Links
Growth of Staphylococcus aureus with defective siderophore production
in human peritoneal dialysate solution.
Park RY, Sun HY, Choi MH, Bae YH, Shin SH.
Research Center for Resistant Cells, Chosun university Medical School,
Gwangju 501-759, Republic of Korea.
In this study, we attempted to determine the effects of
iron-availability and the activity of the bacterial iron-uptake system
(IUS) on the growth of Staphylococcus aureus in human peritoneal
dialysate (HPD) solution. A streptonigrin-resistant S. aureus (SRSA)
strain, isolated from S. aureus ATCC 6538, exhibited defective
siderophore production, thereby resulting in ineffective uptake of iron
from low iron-saturated transferrin. The growth of both strains was
stimulated in HPD solution supplemented with FeCl3 and holotransferrin,
but growth was inhibited in HPD solution which had been supplemented
with apotransferrin and dipyridyl. The SRSA strain grew less robustly
than did its parental strain in both iron-supplemented HPD solution and
regular HPD solution. These results indicate that iron-availability and
siderophore-mediated IUS activity in particular, the ability to produce
siderophores and thus capture iron from low iron-saturated transferrin
play critical roles in the growth of S. aureus in HPD solution. Our
results also indicated that the possibility of using iron chelators as
therapeutic or preventive agents warrants further evaluation.
PMID: 15765059 [PubMed - in process]
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Who loves ya.
Tom
http://herbivore.7h.com
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| Manky Badger 2005-03-23, 5:37 pm |
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<ironjustice@aol.com> wrote in message
news:1111266207.285573.303180@o13g2000cwo.googlegroups.com...
>J Microbiol. 2005 Feb;43(1):54-61. Related Articles, Links
> Who loves ya.
> Tom
>
> http://herbivore.7h.com
Sorry Tom, but if you slip up on something as basic as saying "This page has
NO commercial interest." on your website, which it has to be said is rife
with adverts & spyware, you can't really expect to be taken seriously on
something like a scientific article.
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| ironjustice@aol.com 2005-03-23, 5:38 pm |
| Like .. what .. are .. "adverts and spyware" .. ?
It is a free webhost ..
Free webhost ..
You have anything to SAY .. about .. fkg .. infection .. mr .. labguy
...?
Didn't think so ..
Now fo ..
Screwball ..
Who loves ya.
Tom
http://herbivore.7h.com
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| Manky Badger 2005-03-23, 5:38 pm |
|
<ironjustice@aol.com> wrote in message
news:1111347329.121407.158780@o13g2000cwo.googlegroups.com...
> Like .. what .. are .. "adverts and spyware" .. ?
>
> It is a free webhost ..
>
> Free webhost ..
Says it all, doesn't it.
> You have anything to SAY .. about .. fkg .. infection .. mr .. labguy
> ..?
>
> Didn't think so ..
>
> Now fo ..
>
> Screwball ..
>
Oh so brave when on another continent, aren't we, Yellow !!
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| Manky Badger 2005-03-24, 12:27 pm |
|
<ironjustice@aol.com> wrote in message
news:1111347329.121407.158780@o13g2000cwo.googlegroups.com...
> Like .. what .. are .. "adverts and spyware" .. ?
>
> It is a free webhost ..
>
> Free webhost ..
Says it all, doesn't it.
> You have anything to SAY .. about .. fkg .. infection .. mr .. labguy
> ..?
>
> Didn't think so ..
>
> Now fo ..
>
> Screwball ..
>
Oh so brave when on another continent, aren't we, Yellow !!
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