| ironjustice@aol.com 2005-03-19, 5:36 pm |
| I suppose the article below would give credence to the use of iron
binding substances in the treatment of lung disease.
<<snip>>
Mannitol significantly improved the health status
<<snip>>
Respirology. 2005 Jan;10(1):46-56. Related Articles, Links
Inhaled mannitol for the treatment of mucociliary dysfunction in
patients with bronchiectasis: Effect on lung function, health status
and sputum.
Daviskas E, Anderson SD, Gomes K, Briffa P, Cochrane B, Chan HK, Young
IH, Rubin BK.
Department of Respiratory Medicine, Royal Prince Alfred Hospital,
Sydney, Australia.
Inhaled mannitol for the treatment of mucociliary dysfunction in
patients with bronchiectasis: Effect on lung function, health status
and sputum DAVISKAS E, ANDERSON SD, GOMES K, BRIFFA P, COCHRANE B, CHAN
H-K, YOUNG IH, RUBIN BK. Respirology 2005; 10: 46-56Objective: Inhaled
mannitol increases mucus clearance in patients with bronchiectasis by
an unclear mechanism. The effect of mannitol on lung function, health
status and sputum properties was investigated. Methodology: Nine
patients with bronchiectasis inhaled 400 mg of mannitol once daily for
12 days. Health status was assessed using the St George's Respiratory
Questionnaire (SGRQ). Sputum was analysed for viscosity, elasticity,
spinnability, surface tension, contact angle, solids, mucociliary
transportability (MCTR) on a frog palate, and cough transportability
(CTR) on a simulated cough machine. Results: Lung function was
unchanged with treatment (baseline FEV(1) 82.0 +/- 16.2%) apart from an
improvement in FEF from 85.4 +/- 13% (baseline) to 90.7 +/- 14.4% (P <
0.05; 12th treatment; visit 7). The total SGRQ score (mean +/- SD) of
49.3 +/- 13.8 at baseline, decreased by 12.4 +/- 10.2 (P < 0.01; visit
7) and 10.1 +/- 9.4 units (P < 0.02) 6-10 days after treatment
cessation. The baseline subscores for symptoms (72.9 +/- 11.8),
activity (44.7 +/- 20.9) and impact (44.4 +/- 14.3) were reduced by 0.8
+/- 9.1 (P > 0.7), 8.4 +/- 16.0 (P > 0.1) and 19.2 +/- 13.7 (P < 0.005)
units, respectively (visit 7). Mannitol reduced the baseline (mean +/-
SE) surface tension from 94.5 +/- 1.4 to 84.7 +/- 2.1 mN/m (P <
0.0001), contact angle from 51.1 +/- 2.8 to 33.2 +/- 2.4 degrees (P <
0.0001), spinnability from 11.6 +/- 0.4 to 10.0 +/- 0.2 mm (P < 0.005),
and solids from 5.7 +/- 0.4 to 4.3 +/- 0.7% (P < 0.02), acutely (visit
7). Viscosity, elasticity and MCTR did not change significantly, while
CTR was increased from 25.8 +/- 1.0 to 34.1 +/- 2.7 mm (P < 0.003).
Conclusion: Mannitol significantly improved the health status over 12
days and this improvement was maintained for 6-10 days after cessation
of treatment. In addition, mannitol reduced the tenacity, increased the
hydration of mucus acutely and improved cough clearability in patients
with bronchiectasis.
PMID: 15691238 [PubMed - in process]
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http://www.biochemj.org/bj/224/bj2240761.htm
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://herbivore.7h.com
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