| matthew murphy 2005-03-19, 5:36 pm |
| The link with EPO and auto-immune anaemias, more especially Acquired
auto-immune haemolytic anaemias in humans was tracked to a small group of
dialysis patients, recieving one type of EPO. It is believed that this
caused the formation of red cell antibodies. This is not and has never been
a wide problem with commercial EPO. There is a paper publiushed by the New
England Journal related to Pure Red Cell Aplasia and EPO
Matt
<ironjustice@aol.com> wrote in message
news:1110453941.813039.323070@l41g2000cwc.googlegroups.com...
> Blood. 2004 May 1;103(9):3300-2. Epub 2003 Dec 24. Related Articles,
> Links
>
>
> Erythropoietin gene therapy leads to autoimmune anemia in macaques.
>
> Gao G, Lebherz C, Weiner DJ, Grant R, Calcedo R, McCullough B, Bagg A,
> Zhang Y, Wilson JM.
>
> Gene Therapy Program, Division of Medical Genetics, Department of
> Medicine, university of Pennsylvania, Philadelphia, PA 19104, USA.
>
> Gene therapy is being considered for the delivery of therapeutic
> proteins. We evaluated the delivery of the hormone erythropoietin (EPO)
> into cynomolgus macaques through intramuscularly administered
> adeno-associated virus (AAV) vectors. As expected, the animals
> developed supraphysiologic levels of EPO and polycythemia. However,
> severe anemia ensued in some animals because of an autoimmune response
> to endogenous and transgene derived EPO. This is the first example of
> gene therapy leading to inadvertent auto-immunity in primates.
>
> PMID: 14695227 [PubMed - indexed for MEDLINE]
>
> --------------------------------------------------------------------------
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>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!
> http://herbivore.7h.com
>
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