| ironjustice@aol.com 2005-03-19, 5:36 pm |
| <<snip>>
suggesting the presence of a different type of siderophore
<<snip??
Mem Inst Oswaldo Cruz. 2004 Dec;99(8):839-44. Epub 2005 Mar 4.
suggesting the presence of a different type of siderophoreRelated
Articles, Links
Evaluation of adherence, hemagglutination, and presence of genes
codifying for virulence factors of Acinetobacter baumannii causing
urinary tract infection.
Braun G, Vidotto MC.
Colegiado do Curso de Farmacia, Universidade Estadual do Oeste do
Parana, Cascavel, PR, 85819-110, Brasil.
Acinetobacter baumannii is a strictly aerobic bacterium which causes
severe infections, however its pathogenic characteristics are not well
defined. Thirteen A. baumannii strains isolated from urine of
hospitalized and nonhospitalized patients with different ages were
investigated for the presence of virulence factors. The isolates
belonged to biotypes 2, 6, and 9 and were sensitive to imipenem. The
majority of them showed resistance to amikacin, ceftazidime,
ceftriaxone, ciprofloxacin, gentamicin, norfloxacin, and
trimethoprim-sulfamethoxazole. None of A. baumannii strains presented
genes codifying for 17 different virulence factors previously described
in uropathogenic Escherichia coli, when tested by polymerase chain
reaction (PCR). Nine isolates agglutinated human group AB erythrocytes,
in presence of mannose, but none of them agglutinated group O
erythrocytes. Adherence to polystyrene was observed in 7 isolates, and
this result did not correlate with that obtained in hemagglutination
assay. All the isolates were able to grow in iron-limiting conditions,
showing that A. baumannii produces some type of siderophore. However,
the genes iutA and fyuA, from iron uptake system of E. coli and
Yersinia sp., respectively, were not present in the isolates,
suggesting the presence of a different type of siderophore. The
fimbriae of A. baumannii strains that mediates the adherence are
possibly mannose-resistant, eventhough the mechanism of adherence to
human epithelial cells still remains to be elucidated.
PMID: 15761600 [PubMed - in process]
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