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dermal iron deposition may not be an incidental by-product of increased venous
pressure, but may actively perpetuate tissue damage
<<snip>>
Arch Dermatol. 1988 Sep;124(9):1376-8. Related Articles, Links
Overload of iron in the skin of patients with varicose ulcers. Possible
contributing role of iron accumulation in progression of the disease.
Ackerman Z, Seidenbaum M, Loewenthal E, Rubinow A.
Department of Internal Medicine, Hadassah university Hospital, Jerusalem.
The brown pigmentation of the skin associated with venous ulceration is caused
by increased local iron deposition. Diagnostic x-ray spectrometry, a method
based on x-ray fluorescence analysis, was used for the noninvasive
determination of iron levels in the skin of patients with venous ulceration.
The mean (+/- SEM) iron concentration in the skin around the venous ulcer was
elevated, compared with control values of nonulcerated skin (250 +/- 54 vs 128
+/- 39 micrograms) and compared with normal skin from the forearm (250 +/- 54
vs 14 +/- 2.5 micrograms). These data suggest that dermal iron deposition may
not be an incidental by-product of increased venous pressure, but may actively
perpetuate tissue damage in venous ulcerations.
PMID: 3415280 [PubMed - indexed for MEDLINE]
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