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<<snip>>
middle-aged women with a relatively high haem iron intake have an increased
risk of CHD
<<snip>>
Eur Heart J. 2004 Nov 30; [Epub ahead of print] Related Articles, Links
Dietary haem iron and coronary heart disease in women.
van der A DL, Peeters PH, Grobbee DE, Marx JJ, van der Schouw YT.
Julius Center for Health Sciences and Primary Care, university Medical Center
Utrecht, HP Str.6.131, PO Box 85500, 3508 GA Utrecht, The Netherlands.
AIMS: A role for iron in the risk of ischaemic heart disease has been supported
by in vitro and in vivo studies. We investigated whether dietary haem iron
intake is associated with coronary heart disease (CHD) risk in a large
population-based cohort of middle-aged women. METHODS AND RESULTS: We used data
of 16 136 women aged 49-70 years at recruitment between 1993 and 1997.
Follow-up was complete until 1 January 2000 and 252 newly diagnosed CHD cases
were documented. Cox proportional hazards analysis was used to estimate hazard
ratios of CHD for quartiles of haem iron intake, adjusted for cardiovascular
and nutritional risk factors. We stratified by the presence of additional
cardiovascular risk factors, menstrual periods, and antioxidant intake to
investigate the possibility of effect modification. High dietary haem iron
intake was associated with a 65% increase in CHD risk [hazard ratio (HR)=1.65;
95% confidence interval (CI): 1.07-2.53], after adjustment for cardiovascular
and nutritional risk factors. This risk was not modified by additional risk
factors, menstruation, or antioxidant intake. CONCLUSION: The results indicate
that middle-aged women with a relatively high haem iron intake have an
increased risk of CHD.
PMID: 15618055 [PubMed - as supplied by publisher]
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