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| Eur J Gastroenterol Hepatol. 2004 Sep;16(9):943-5. Related Articles, Links
Granulocyte, macrophage, monocyte apheresis for refractory ulcerative
proctitis.
Premchand P, Takeuchi K, Bjarnason I.
Department of Gastroenterology, Guy's School of Medicine, London SE5 9PJ, UK.
purushothaman.premchand@gstt.nhs.uk
Refractory ulcerative colitis that fails conventional intense medical treatment
often leads to colectomy. Although ciclosporin and infliximab may avert
colectomy in certain cases, these treatments come with substantial toxicity and
may only act as a bridge to avert emergency surgery. Granulocyte
monocyte/macrophage adsorption apheresis is a new treatment and has shown
efficacy for refractory colitis in up to 80% of cases in a Japanese study and
is apparently only associated with negligible side effects. We report a case of
severe refractory proctitis destined for colectomy effectively treated with
granulocyte monocyte/macrophage adsorption apheresis. After two of five
sessions the patient achieved full clinical remission, which has been sustained
with the addition of azathioprine for more than 1 year.
Publication Types:
Case Reports
PMID: 15316424 [PubMed - indexed for MEDLINE]
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