Pathology - Contraversial effect of estrogen on Atherosclerosis and Thrombosis

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Contraversial effect of estrogen on Atherosclerosis and Thrombosis

Jinkuk Kim

2004-11-03, 11:10 am

Estrogen is known to protect premenopausal women from cardiovascular
disease such as Atherosclerosis. However I've heard that Estrogen
incleases thrombosis.

Could you explain this paradoxical results to me?
Thanks

Robert

2004-11-03, 7:12 pm

"Jinkuk Kim" <dalsan@sparcs.org> wrote in message
news:761b16e3.0411030825.64bdbbda@posting.google.com...
> Estrogen is known to protect premenopausal women from cardiovascular
> disease such as Atherosclerosis. However I've heard that Estrogen
> incleases thrombosis.
>
> Could you explain this paradoxical results to me?
> Thanks

Pregnancy is associated with an increase in coagulation factors. Coagulation
factors especially factor VIII and fibrinogen are increased in response to
inflammation and in pregnancy. Heparin binding protein is affected by sex as
is pregnancy. Daily oral estrogens decreases antithrombin activity along
with anti-factor Xa activity. These all impact on the coagulation cascade
that renders it more favorable for clotting and thrombosis.
As far as estrogens role in atherosclerosis, it is still being worked out. A
model from mice is being used. This model is now being used to examine the
underlying mechanism(s) of the estrogen protection. The hypotheses being
tested: 1) estrogen acts as an antioxidant, reducing lipoprotein oxidation;
2) estrogen acts as an anti-inflammatory and 3) estrogen mediates favorable
alterations in the immune system. That's from one group of researchers.
..

Jinkuk Kim

2004-11-05, 7:13 pm

Thank you very much.
Could you let me know what is the one group you mentioned?

"Robert" <RobertJ@hotmail.com> wrote in message news:<10oiaefih72bn34@corp.supernews.com>...
> "Jinkuk Kim" <dalsan@sparcs.org> wrote in message
> news:761b16e3.0411030825.64bdbbda@posting.google.com...
>
> Pregnancy is associated with an increase in coagulation factors. Coagulation
> factors especially factor VIII and fibrinogen are increased in response to
> inflammation and in pregnancy. Heparin binding protein is affected by sex as
> is pregnancy. Daily oral estrogens decreases antithrombin activity along
> with anti-factor Xa activity. These all impact on the coagulation cascade
> that renders it more favorable for clotting and thrombosis.
> As far as estrogens role in atherosclerosis, it is still being worked out. A
> model from mice is being used. This model is now being used to examine the
> underlying mechanism(s) of the estrogen protection. The hypotheses being
> tested: 1) estrogen acts as an antioxidant, reducing lipoprotein oxidation;
> 2) estrogen acts as an anti-inflammatory and 3) estrogen mediates favorable
> alterations in the immune system. That's from one group of researchers.
> .

Jinkuk Kim

2004-11-05, 7:13 pm

One more question..
How is oxidized lipoprotein (LDL?) related vardiovascular disease?
Does it increase transportability of cholesterol from tissue to serum?

Thanks

"Robert" <RobertJ@hotmail.com> wrote in message news:<10oiaefih72bn34@corp.supernews.com>...
> "Jinkuk Kim" <dalsan@sparcs.org> wrote in message
> news:761b16e3.0411030825.64bdbbda@posting.google.com...
>
> Pregnancy is associated with an increase in coagulation factors. Coagulation
> factors especially factor VIII and fibrinogen are increased in response to
> inflammation and in pregnancy. Heparin binding protein is affected by sex as
> is pregnancy. Daily oral estrogens decreases antithrombin activity along
> with anti-factor Xa activity. These all impact on the coagulation cascade
> that renders it more favorable for clotting and thrombosis.
> As far as estrogens role in atherosclerosis, it is still being worked out. A
> model from mice is being used. This model is now being used to examine the
> underlying mechanism(s) of the estrogen protection. The hypotheses being
> tested: 1) estrogen acts as an antioxidant, reducing lipoprotein oxidation;
> 2) estrogen acts as an anti-inflammatory and 3) estrogen mediates favorable
> alterations in the immune system. That's from one group of researchers.
> .

Robert

2004-11-05, 10:08 pm

If you do a google search you will find many things on oxidized LDL and just
about anything else. You can also search the NIH Pubmed search engine for
medical articles.

"Jinkuk Kim" <dalsan@sparcs.org> wrote in message
news:761b16e3.0411051053.57add6bb@posting.google.com...
> One more question..
> How is oxidized lipoprotein (LDL?) related vardiovascular disease?
> Does it increase transportability of cholesterol from tissue to serum?
>
> Thanks
>
> "Robert" <RobertJ@hotmail.com> wrote in message
news:<10oiaefih72bn34@corp.supernews.com>...[vbcol=seagreen]
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out. A[vbcol=seagreen]
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Jinkuk Kim

2004-11-09, 7:12 pm

Robert

2004-12-16, 9:08 am

val mirov

2004-12-16, 9:08 am

If your doctor suspects that you have thrombosis or embolism, he or she
will have you admitted to the hospital immediately for treatment.
They'll measure the blood flow through the veins using pulse volume
recording and imaging such as Doppler ultrasound scanning. Then you may
be given drugs to dissolve the clot.

Jinkuk Kim wrote:
> Estrogen is known to protect premenopausal women from cardiovascular
> disease such as Atherosclerosis. However I've heard that Estrogen
> incleases thrombosis.
>
> Could you explain this paradoxical results to me?
> Thanks