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Data suggest a relationship between hepatic iron overload and insulin
resistance, and a role for both iron overload and insulin resistance in
hepatocellular damage
<<snip>>
Liver Int. 2004 Oct;24(5):471-6. Related Articles, Links
Effects of venesections and restricted diet in patients with the
insulin-resistance hepatic iron overload syndrome.
Piperno A, Vergani A, Salvioni A, Trombini P, Vigano M, Riva A, Zoppo A, Boari
G, Mancia G.
Clinica Medica, Universita degli Studi di Milano-Bicocca, Azienda Ospedaliera
San Gerardo Monza, Italy.
Piperno A, Vergani A, Salvioni A, Trombini P, Vigano M, Riva A, Zoppo A, Boari
G, Mancia G. Effects of venesections and restricted diet in patients with the
insulin-resistance hepatic iron overload syndrome. Liver International 2004:
24: 471-476. (c) Blackwell Munksgaard 2004 Abstract: Goal: We evaluated the
effect of venesections and restricted diet on iron and metabolic indices and
liver function tests in patients with insulin-resistance hepatic iron overload
(IR-HIO). Materials and methods: Patients were divided in three groups: (a)
patients without any therapy who were followed-up for 36+28 months; (b)
patients venesected; and (c) patients on dietary treatment. In each group
baseline and end-point levels of serum iron and metabolic indices, and liver
function tests were compared by Student's paired t-test and the relationship
between serum ferritin and the other variables during treatment was evaluated
by linear regression analysis. Findings and conclusions: In the follow-up
group, iron and metabolic indices did not change over time. Serum alanine
aminotransferase, gamma-glutamyl transferase, cholesterol and triglycerides
significantly decreased after iron depletion. Serum glucose, cholesterol,
triglyceride, ferritin and liver function tests significantly decreased after
dietary treatment. Transferrin saturation decreased below 20% during phlebotomy
treatment in 52% of the patients. In conclusion, our results show that IR-HIO
patients had relatively low amount of iron overload that seems not to increase
even after a long follow-up period. Both venesections and diet improved iron,
metabolic and hepatic indices. Data suggest a relationship between hepatic iron
overload and insulin resistance, and a role for both iron overload and insulin
resistance in hepatocellular damage. The behaviour of iron indices during
venesections suggests an impaired iron release from hepatic cells.
PMID: 15482345 [PubMed - in process]
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