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| Med Hypotheses. 2004;63(5):793-809. Links
Elevated levels of ferrimagnetic metals in foodchains supporting the Guam
cluster of neurodegeneration: Do metal nucleated crystal contaminents evoke
magnetic fields that initiate the progressive pathogenesis of
neurodegeneration?
Purdey M.
High Barn Farm, Elworthy, Taunton, Somerset TA4 3PX, UK.
Elevated levels of aluminium (Al), strontium (Sr), barium (Ba), iron (Fe),
manganese (Mn) cations - combined with deficiencies of magnesium (Mg)/calcium
(Ca) - have been observed in the foodchains that traditionally support the
Chamorro populations affected by high incidence clusters of Alzheimer (AD),
Parkinson-like (PD), motor neurone diseases and multiple sclerosis on the
island of Guam. Soils drawn from the cluster region demonstrated an excessive
fivefold increase in 'magnetic susceptibility' readings in relation to soils
from disease free adjoining regions. A multifactorial aetiological hypothesis
is proposed that pivots upon the combined exposure to high levels of
natural/industrial sources of ferrimagnetic/ferroelectric compounds
incorporating Al, Fe, Mn, Sr, Ba (e.g., via yam/seafood consumption or exposure
to world war 2 (WW2) munitions) and to low levels of Mg/Ca in all S. Pacific
locations where these clusters of neurodegenerative disease have simultaneously
erupted. Once gut/blood brain barrier permeability is impaired, the increased
uptake of Al, Fe, Sr, Ba, or Mn into the Mg/Ca depleted brain leads to rogue
metal substitutions at the Mg/Ca vacated binding domains on various
enzyme/proteoglycan groups, causing a broad ranging disruption in Mg/Ca
dependent systems - such as the glutamine synthetase which prevents the
accumulation of neurotoxic glutamate. The rogue metals chelate sulphate,
disrupting sulphated-proteoglycan mediated inhibition of crystal proliferation,
as well as its regulation of the Fibroblast growth factor receptor complex
which disturbs the molecular conformation of those receptors and their
regulation of transphosphorylation between intracellular kinase domains;
ultimately collapsing proteoglycan mediated cell-cell signalling pathways which
maintain the growth and structural integrity of the neuronal networks. The
depression of Mg/Ca dependent systems in conjunction with the progressive
ferrimagnetisation of the CNS due to an overload of rogue
ferroelectric/ferrimagnetic metal contaminants, enables 'seeding' of
metal-protein crystalline arrays that can proliferate in the proteoglycan
depleted brain. The resulting magnetic field emissions initiate a free radical
mediated progressive pathogenesis of neurodegeneration. The co-clustering of
these various types of disease in select geographical pockets around the world
suggests that all of these conditions share a common early life exposure to
ferromagnetic metal nucleating agents in their multifactorial aetiology.
Factors such as individual genetics, the species of metal involved, etc.,
dictate which specific class of disease will emerge as a delayed neurotoxic
response to these environmental insults.
PMID: 15488650 [PubMed - in process]
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