|
| Acta Med Okayama. 2004 Jun;58(3):111-8. Related Articles, Links
Natural antioxidants may prevent posttraumatic epilepsy: a proposal based on
experimental animal studies.
Mori A, Yokoi I, Noda Y, Willmore LJ.
Okayama University, Okayama 700 8558, Japan. dr-mori@f3.dion.ne.jp
Head injury or hemorrhagic cortical infarction results in extravasation of
blood and breakdown of red blood cells and hemoglobin. Iron liberated from
hemoglobin, and hemoglobin itself, are associated with the generation of
reactive oxygen species (ROS) and reactive nitrogen species (RNS). ROS and RNS
have been demonstrated to be involved in the mechanism of seizures induced by
iron ions in the rat brain, an experimental animal model for posttraumatic
epilepsy (PTE). ROS are responsible for the induction for peroxidation of
neural lipids, i.e., an injury of neuronal membranes, and also could induce
disorders in the excitatory and inhibitory neurotransmitters. Antioxidants,
such as a phosphate diester of vitamin E and C (EPC-K1) and antiepileptic
zonisamide, have been known to prevent the epileptogenic focus formation, or to
attenuate seizure activities in the iron-injected rat brain. Natural
antioxidants, such as alpha-tocopherol, and condensed tannins, including
(-)-epigallocatechin and (-)-epigallocatechin-3-O-gallate, adenosine and its
derivative, melatonin, uyaku (Lindera Strychnifolia), fermented papaya
preparations, Gastrodia elata BI., and Guilingji, have been demonstrated to
scavenge ROS and/or RNS and to be prophylactic for the occurrence of epileptic
discharge in the iron-injected rat brain.
PMID: 15471432 [PubMed - in process]
--------------------------------------------------------------------------
------
Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore! http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING http://pages.ivillage.com/ironjustice/deadpeoplewalking
|
|