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Elevated iron stores were positively associated with the prevalence of the
metabolic syndrome and with insulin resistance.
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Diabetes Care. 2004 Oct;27(10):2422-8. Related Articles, Links
Serum ferritin and risk of the metabolic syndrome in u.s. Adults.
Jehn M, Clark JM, Guallar E.
DrPH, Welch Center for Prevention, Epidemiology & Clinical Research, 2024 E.
Monument St., Suite 2-639, Baltimore, MD 21205. eguallar@jhsph.edu
OBJECTIVE: We examined the relationship among iron stores, the metabolic
syndrome, and insulin resistance. RESEARCH DESIGN AND METHODS: We conducted a
cross-sectional study of 6,044 adults >20 years of age who participated in the
Third National Health and Nutrition Examination Survey. Metabolic syndrome was
defined as the presence of at least three of the following: elevated blood
pressure, low HDL cholesterol, elevated serum triglycerides, elevated plasma
glucose, and abdominal obesity. Insulin resistance was estimated using
homeostasis model assessment (for insulin resistance), fasting insulin, and
triglyceride-to-HDL cholesterol ratio. RESULTS: After excluding individuals
with likely hemochromatosis, mean serum ferritin values in premenopausal women,
postmenopausal women, and men were 33.6, 93.4, and 139.9 microg/l,
respectively. Metabolic syndrome was more common in those with the highest
compared with the lowest levels of serum ferritin in premenopausal women (14.9
vs. 6.4%, P = 0.002), postmenopausal women (47.5 vs. 28.2%, P < 0.001), and men
(27.3 vs. 13.8%, P < 0.001). Insulin resistance also increased across quartiles
of serum ferritin for men and postmenopausal women and persisted after
adjustment for age, race/ethnicity, C-reactive protein, smoking, alcohol
intake, and BMI. CONCLUSIONS: Elevated iron stores were positively associated
with the prevalence of the metabolic syndrome and with insulin resistance.
PMID: 15451911 [PubMed - in process]
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