| ironjustice@aol.com 2006-09-15, 9:32 pm |
| <<snip>>
Supplementation with alpha-Tocopherol may protect G6PD activity from
reduction
<<snip>>
alpha-Tocopherol supplementation restores the reduction of erythrocyte
glucose-6-phosphate dehydrogenase activity induced by forced training.
Tsakiris S, Reclos GJ, Parthimos T, Tsakiris T, Parthimos N, Schulpis
KH
Pharmacol Res. 2006 Aug 7;
BACKGROUND: Erythrocyte glucose-6-phosphate dehydrogenase (G6PD)
activity is closely related to free radical production.
alpha-Tocopherol (alpha-T) is implicated with the reduction of lipid
peroxidation. AIM: To investigate the effect of training and alpha-T
supplementation on the erythrocyte G6PD activity. METHODS: Blood was
obtained from 10 basketball players pre-game (group A), post-game
(group B) and after 30 days on alpha-T (dl-alpha-tocopheryl-acetate,
200mg 24h(-1) orally) supplementation pre- (group C) and post-training
(group D). alpha-T and catecholamines were evaluated with HPLC methods
and creatine kinase, lactate dehydrogenase, total antioxidant status
(TAS) and G6PD activity with commercial kits. RESULTS: TAS was
increased in the groups with alpha-T addition (groups C and D).
Post-exercise, TAS and G6PD activity were remarkably higher
(2.10+/-0.13mmoll(-1), 7.92+/-1.5Ug(-1)Hb, respectively) in group D
than those in group B (0.92+/-0.10mmoll(-1), 4.8+/-1.4Ug(-1)Hb, p<0.01,
respectively). G6PD activity positively correlated with TAS (r=3D0.64,
p<0.001) in all the studied groups. CONCLUSIONS: Supplementation with
alpha-T may protect G6PD activity from reduction induced by forced
training.
---------------------------------------------------------------------------=
-----------------
Iron destroys tocopherol by oxidation and 'coincidentally' ..
tocopherol deficiency results in hemolytic anemia.
The study below shows by .. targeting .. **iron** .. "shortens the
duration of the crisis and decreases the amount of blood transfusion
needed."
---------------------------------------------------------------------------=
-----------------
Acta Haematol. 1999;101(3):145-8. Related Articles, Links
Effect of desferrioxamine in acute haemolytic anaemia of
glucose-6-phosphate dehydrogenase deficiency.
al-Rimawi HS, al-Sheyyab M, Batieha A, el-Shanti H, Abuekteish F.
Department of Paediatrics, Faculty of Medicine, Jordan university of
Science and Technology, Irbid, Jordan.
The effectiveness of desferrioxamine (DFO) in ameliorating the severity
of the acute haemolysis of glucose-6-phosphate dehydrogenase (G6PD)
deficiency was studied in 167 children with G6PD deficiency during an
acute haemolytic crisis. All patients received packed cell transfusion
on admission if their Hb levels were <8 g/dl, which was repeated as
needed. Eighty patients also received a single dose of DFO 30-40 mg/kg
by slow intravenous infusion (DFO group). The remaining 87 children did
not receive DFO (control group). The need for more than one transfusion
was less frequent in the DFO group as compared to the control group (p
=3D 0. 01). The need for late transfusion (transfusion after 36 h of
admission) was also less in the DFO group (7%) compared to 21% in the
control group (p =3D 0.02). On average, children in the DFO group needed
less packed red blood cells (16.5 ml/kg body weight) than the control
group (22.8 ml/kg body weight) and the difference was highly
significant (p =3D 0.0001). We conclude from this study that DFO in a
small dose is effective in the treatment of acute haemolytic crises of
G6PD deficiency. It shortens the duration of the crisis and decreases
the amount of blood transfusion needed.
Publication Types:
Clinical Trial
Controlled Clinical Trial
PMID: 10352334 [PubMed - indexed for MEDLINE]
---------------------------------------------------------------------------=
=AD-----
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://tinyurl.com/a3cc3
DEAD PEOPLE WALKING=20
http://tinyurl.com/zk9fk
|