| ironjustice@aol.com 2005-07-20, 2:04 pm |
| Oxidative stress and acute-phase response in patients with pressure
sores.
Cordeiro MB, Antonelli EJ, Ferreira da Cunha D, Jord=E3o J=FAnior AA,
Rodrigues J=FAnior V, Vannucchi H
Nutrition. 2005 Jul 15;
OBJECTIVE: We investigated the relation between oxidative stress and
the occurrence of the acute-phase response with serum ascorbic acid and
alpha-tocopherol levels in patients with pressure sores. METHODS: The
following groups of patients were studied: 1) those who had patients
with pressure sores, 2) those who had pneumonia, and 3) those who did
not develop pressure sores or any type of infection (control).
Concentrations of total proteins, albumin, creatinine, iron, ferritin,
transferrin, C-reactive protein, alpha(1)-acid glycoprotein, total
iron-binding capacity, ascorbic acid, alpha-tocopherol, and
malondialdehyde were measured during the first days of hospitalization.
RESULTS: Albumin concentrations were significantly lower (P < 0.05) and
C-reactive protein concentrations were significantly higher (P < 0.05)
in patients with pressure sores compared with controls. Concentrations
of ascorbic acid and alpha-tocopherol were significantly decreased (P <
0=2E05) in patients who had pressure sores or infection, whereas
malondialdehyde concentrations were significantly increased (P < 0.05)
compared with control patients. Five of 11 patients (55.56%) with
pressure sores and 10 of 12 patients (83.33%) with pneumonia presented
serum ascorbic acid concentrations below the reference value (34 to 91
mumol/L). Concentrations of ascorbic acid and alpha-tocopherol versus
malondialdehyde were significantly correlated in the three patient
groups (r =3D -0.44, P < 0.05; r =3D -0.55, P < 0.01, respectively).
CONCLUSION: Patients with pressure sores and acute infection present a
systemic inflammatory response accompanied by an increase in lipid
peroxidation that is associated with decreased serum ascorbic acid and
alpha-tocopherol levels, suggesting that these patients may be at risk
for important nutritional deficiencies.
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