| ironjustice@aol.com 2005-06-27, 10:00 am |
| <<snip>>
Stored iron seems to impact negatively on insulin action even in
healthy people, and not just in classic pathologic conditions
associated with iron overload (hemochromatosis and hemosiderosis)
<<snip>>
Clin Chem. 2005 Jul;51(7):1201-5. Links
Iron stores, blood donation, and insulin sensitivity and secretion.
Fernandez-Real JM, Lopez-Bermejo A, Ricart W.
Section of Diabetes, Endocrinology and Nutrition, university Hospital
of Girona "Dr Josep Trueta", Girona, Spain.
BACKGROUND: Epidemiologists have observed that blood donation is
associated with decreased risk of type 2 diabetes and cardiovascular
disease. METHODS: We investigated the relationship between iron stores
and insulin sensitivity, after controlling for known confounding
factors, and compared insulin sensitivity between blood donors and
individuals who had never donated blood (nondonors). In 181 men,
insulin sensitivity and insulin secretion were evaluated through
frequently sampled intravenous glucose tolerance tests with minimal
model analysis. Men who donated blood between 6 months and 5 years
before inclusion (n =3D 21) were carefully matched with nondonors (n =3D
66) for age, body mass index, waist-to-hip ratio, and cardiovascular
risk profile, including blood lipids, blood pressure, and smoking
status. RESULTS: Frequent blood donors (2-10 donations) had increased
insulin sensitivity [3.42 (1.03) vs 2.45 (1.2) x 10(-4) . min(-1) .
mIU/L; P =3D 0.04], decreased insulin secretion [186 (82) vs 401.7 (254)
mIU/L . min; P <0.0001], and significantly lower iron stores [serum
ferritin, 101.5 (74) vs 162 (100) mug/L; P =3D 0.017] than nondonors, but
the 2 groups had similar blood hematocrits and blood hemoglobin
concentrations. CONCLUSIONS: Blood donation is simultaneously
associated with increased insulin sensitivity and decreased iron
stores. Stored iron seems to impact negatively on insulin action even
in healthy people, and not just in classic pathologic conditions
associated with iron overload (hemochromatosis and hemosiderosis).
According to these observations, it is imperative that a definition of
excessive iron stores in healthy people be formulated.
PMID: 15976100 [PubMed - in process]
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