| ironjustice@aol.com 2005-06-15, 12:18 pm |
| So would the 'mode of action' of Pentoxifylline BE the SAME as
theophylline .. used in asthma patients .. the lowering of the red
blood cell count / bloodletting / hemodilution .. treatment OF .. the
ADMITTED increased blood cell count found IN .. diabetics .. ?
J Med. 1988;19(2):89-107. Related Articles, Links
Pentoxifylline (Trental)--a new drug for the treatment of peripheral
chronic occlusive arterial disease.
Chopra HK, Chopra KL, Aggarwal KK, Parashar SK.
Mool Chand K.R. Hospital, Lajpat Nagar III, New Delhi, India.
Pentoxifylline (Trental), a xanthine analog, was evaluated for
tolerance, safety and efficacy in the treatment of chronic arterial
disease in a pilot study. Evaluation was performed in 35 cases. Twenty
patients (Fontaine stage II or stage III severity) were given
pentoxifylline in a daily dose of 1200 mg (Trental 400 t.i.d.) and 15
patients were given placebo for a period of eight weeks, respectively.
Pentoxifylline was significantly more effective than the placebo in
increasing both the initial and absolute claudication distance (ICD and
ACD) in patients with peripheral chronic occlusive arterial disease
(COAD). The subjective parameters such as paresthesias, muscular cramps
and sensation of heaviness in the legs paralled the course of walking
parameters. These results support the hypothesis that pentoxifylline in
doses of 400 mg (slow release tablets) t.i.d. enhances blood flow via
reducing blood viscosity and improving red cell flexibility in patients
with intermittent claudication due to COAD. Pentoxifylline is thus
regarded as a promising drug for the treatment of circulatory ischemic
disorders, especially in intermittent claudication. It was well
tolerated with minimal untoward effects.
Publication Types:
Case Reports
Clinical Trial
Controlled Clinical Trial
Review
Review of Reported Cases
PMID: 3049876 [PubMed - indexed for MEDLINE]
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