| ironjustice@aol.com 2005-06-15, 12:18 pm |
| The second study I placed quite a while ago http://tinyurl.com/7eq9c
and argued long and hard that this increase of red blood cell count
would .. OBVIOUSLY .. lead to .. hyperviscosity .. / THICK BLOOD .. and
since the first study below says .. OUTRIGHT .. diabetics HAVE ..
thick blood .. this would mean .. I .. am .. right .. one .. more ..
time ..
Heh .. heh ..
Erythrocytosis / increased red blood cell mass .. leads to ..
hyperviscosity / thick blood ..
Atherosclerosis. 2005 Jul;181(1):101-8. Related Articles, Links
The metabolic syndrome and insulin resistance: relationship to
haemostatic and inflammatory markers in older non-diabetic men.
Wannamethee SG, Lowe GD, Shaper AG, Rumley A, Lennon L, Whincup PH.
Department of Primary Care and Population Sciences, Royal Free and
University college Medical School, Rowland Hill St, London NW3 2PF, UK.
AIMS:: We have examined the cross-sectional relationship between
insulin resistance, the metabolic syndrome and haemostatic and
inflammatory markers. METHODS AND RESULTS:: We carried out the study in
2722 non-diabetic men aged 60-79 years with no history of coronary
heart disease or stroke and who were not on warfarin treatment, drawn
from general practices in 24 British towns. Insulin resistance (HOMA)
was significantly associated with increased inflammatory markers
(C-reactive protein (CRP), white cell count), coagulation factors
VII-IX, von Willebrand factor (VWF) and tissue plasminogen activator
(t-PA) antigens (markers of endothelial dysfunction) and blood
viscosity after adjustment for age, smoking, physical activity, alcohol
intake and waist circumference. Relationships with fibrinogen and
fibrin D-dimer were weak. The relationship between HOMA and CRP was
abolished after adjustment for t-PA. The prevalence of the metabolic
syndrome was similar using World Health Organization (WHO) and National
Cholesterol education Program definitions (26.7% and 27.0%) but
associations between the metabolic syndrome and increased haemostatic
markers, particularly for raised factor VIII and VWF were stronger
using WHO criteria. CONCLUSION:: Insulin resistance and the metabolic
syndrome showed significant associations with markers of haemostasis
and inflammation, which may be relevant to their associations with
cardiovascular disease.
PMID: 15939060 [PubMed - in process]
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Diabetologia. 2001 Oct;44(10):1232-7. Related Articles, Links
New aspects of the insulin resistance syndrome: impact on
haematological parameters.
Barbieri M, Ragno E, Benvenuti E, Zito GA, Corsi A, Ferrucci L,
Paolisso G.
Department of Geriatric Medicine and Metabolic Diseases, university of
Naples, Italy.
AIM/HYPOTHESIS: Previous studies have shown that insulin has an
important in vitro role in the regulation of human erythropoiesis. We
investigated whether in vivo hyperinsulinaemia/insulin resistance
affects haematological parameters. METHODS: A total of 608 subjects
between 22 and 99 years of age were enrolled in the Chianti study, an
epidemiological study of factors affecting mobility in old age. The
degree of insulin resistance was assessed using the homeostasis model.
RESULTS: We found a correlation between insulin resistance and red
blood cell count, (r = 0.14 p < 0.001), plasma haemoglobin (r = 0.16 p
< 0.001), haematocrit (r = 0.15 p < 0.001) and plasma iron (r = 0.1 p <
0.05) concentrations. Red blood cell count was also associated with the
other biological markers of insulin resistance syndrome. Subjects with
higher insulin resistance (4 degrees quartile) had higher red blood
cell count, plasma triglycerides and low density lipoproteins (LDL)
cholesterol concentrations and lower high density lipoproteins (HDL)
cholesterol concentrations then subjects at the lowest quartiles of
insulin resistance. Insulin resistance and BMI were significant and
independent predictors of red blood cell count even when the analysis
was adjusted for age, sex, waist-to-hip ratio, plasma iron and drug
intake. CONCLUSION/HYPOTHESIS: Our findings provide in vivo evidence of
a relation between hyperinsulinaemia/insulin resistance, the main
variables of insulin resistance syndrome and erythropoiesis. Increased
red blood cell count could be considered as a new aspect of the insulin
resistance syndrome that could contribute to the increased risk of
developing cardiovascular problems.
PMID: 11692171 [PubMed - indexed for MEDLINE]
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