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| T cells activated in the gut during inflammatory bowel disease can be re-routed
to the liver and cause chronic liver disease, according to Eksteen and
colleagues in the December 1 issue of The Journal of Experimental Medicine.
A chronic liver disease known as primary sclerosing cholangitis (PSC) has been
linked to inflammatory bowel disease (IBD) in the past. But the connection
between the two disorders has been unclear, especially as the liver condition
often develops years after IBD has resolved or the colon has been surgically
removed. Eksteen and colleagues now show that T cells that were activated in the
gut – probably during IBD - are found in the livers of patients with PSC, but
not in those of patients with other inflammatory liver diseases.
The authors explain this detour by showing that an attractant protein that
normally directs T cells into the gut is aberrantly produced in the liver during
PSC. T cells expressing the receptor for the protein are thus re-routed to the
liver, although the authors do not know what triggers liver cells to make the
attractant in the first place. T cells can survive as memory cells for many
years after they are activated, and the authors believe this may explain how the
liver disease can crop up years after IBD has resolved.
This story has been adapted from a news release issued by Journal Of
Experimental Medicine.
Alan
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