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Home > Archive > Hepatitis disease > August 2005 > Treatment of Chronic Hepatitis C Virus Infection via Antioxidants
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Treatment of Chronic Hepatitis C Virus Infection via Antioxidants
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| ironjustice@aol.com 2005-08-09, 5:58 pm |
| J Clin Gastroenterol. 2005 Sep;39(8):737-742. Related Articles, Links
Treatment of Chronic Hepatitis C Virus Infection via Antioxidants:
Results of a Phase I Clinical Trial.
Melhem A, Stern M, Shibolet O, Israeli E, Ackerman Z, Pappo O, Hemed N,
Rowe M, Ohana H, Zabrecky G, Cohen R, Ilan Y.
>From the *Liver Unit, Department of Medicine, and daggerDepartment of
Pathology, Hebrew University, Hadassah Medical Center, Jerusalem,
Israel; and double daggerMarcus Foundation, Atlanta, GA.
BACKGROUND:: The pathogenesis of chronic hepatitis C virus (HCV)
infection is associated with a defective host antiviral immune response
and intrahepatic oxidative stress. Oxidative stress and lipid
peroxidation play major roles in the fatty liver accumulation
(steatosis) that leads to necro-inflammation and necrosis of hepatic
cells. Previous trials suggested that antioxidative therapy may have a
beneficial effect on patients with chronic HCV infection. AIMS:: To
determine the safety and efficacy of treatment of chronic HCV patients
via a combination of antioxidants. METHODS:: Fifty chronic HCV patients
were treated orally on a daily basis for 20 weeks with seven
antioxidative oral preparations (glycyrrhizin, schisandra, silymarin,
ascorbic acid, lipoic acid, L-glutathione, and alpha-tocopherol), along
with four different intravenous preparations (glycyrrhizin, ascorbic
acid, L-glutathione, B-complex) twice weekly for the first 10 weeks,
and followed up for an additional 20 weeks. Patients were monitored for
HCV-RNA levels, liver enzymes, and liver histology. Assessment of
quality of life was performed using the SF-36 questionnaire. RESULTS::
In one of the tested parameters (eg, liver enzymes, HCV RNA levels, or
liver biopsy score), a combination of antioxidants induced a favorable
response in 48% of the patients (24). Normalization of liver enzymes
occurred in 44% of patients who had elevated pretreatment ALT levels
(15 of 34). ALT levels remained normal throughout follow-up period in
72.7% (8 of 11). A decrease in viral load (one log or more) was
observed in 25% of the patients (12). Histologic improvement (2-point
reduction in the HAI score) was noted in 36.1% of the patients. The
SF-36 score improved in 26 of 45 patients throughout the course of the
trial (58% of the patients). Treatment was well tolerated by all
patients. No major adverse reactions were noted. CONCLUSIONS:: These
data suggest that multi antioxidative treatment in chronic HCV patients
is well tolerated and may have a beneficial effect on
necro-inflammatory variables. A combination of antiviral and
antioxidative therapies may enhance the overall response rate of these
patients.
PMID: 16082287 [PubMed - as supplied by publisher]
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Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/ironjustice/deadpeoplewalking
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| outrider 2005-08-09, 5:58 pm |
| Thanks Tom. Zee
ironjustice@aol.com wrote:
> J Clin Gastroenterol. 2005 Sep;39(8):737-742. Related Articles, Links
>
>
> Treatment of Chronic Hepatitis C Virus Infection via Antioxidants:
> Results of a Phase I Clinical Trial.
>
> Melhem A, Stern M, Shibolet O, Israeli E, Ackerman Z, Pappo O, Hemed N,
> Rowe M, Ohana H, Zabrecky G, Cohen R, Ilan Y.
>
> Pathology, Hebrew University, Hadassah Medical Center, Jerusalem,
> Israel; and double daggerMarcus Foundation, Atlanta, GA.
>
> BACKGROUND:: The pathogenesis of chronic hepatitis C virus (HCV)
> infection is associated with a defective host antiviral immune response
> and intrahepatic oxidative stress. Oxidative stress and lipid
> peroxidation play major roles in the fatty liver accumulation
> (steatosis) that leads to necro-inflammation and necrosis of hepatic
> cells. Previous trials suggested that antioxidative therapy may have a
> beneficial effect on patients with chronic HCV infection. AIMS:: To
> determine the safety and efficacy of treatment of chronic HCV patients
> via a combination of antioxidants. METHODS:: Fifty chronic HCV patients
> were treated orally on a daily basis for 20 weeks with seven
> antioxidative oral preparations (glycyrrhizin, schisandra, silymarin,
> ascorbic acid, lipoic acid, L-glutathione, and alpha-tocopherol), along
> with four different intravenous preparations (glycyrrhizin, ascorbic
> acid, L-glutathione, B-complex) twice weekly for the first 10 weeks,
> and followed up for an additional 20 weeks. Patients were monitored for
> HCV-RNA levels, liver enzymes, and liver histology. Assessment of
> quality of life was performed using the SF-36 questionnaire. RESULTS::
> In one of the tested parameters (eg, liver enzymes, HCV RNA levels, or
> liver biopsy score), a combination of antioxidants induced a favorable
> response in 48% of the patients (24). Normalization of liver enzymes
> occurred in 44% of patients who had elevated pretreatment ALT levels
> (15 of 34). ALT levels remained normal throughout follow-up period in
> 72.7% (8 of 11). A decrease in viral load (one log or more) was
> observed in 25% of the patients (12). Histologic improvement (2-point
> reduction in the HAI score) was noted in 36.1% of the patients. The
> SF-36 score improved in 26 of 45 patients throughout the course of the
> trial (58% of the patients). Treatment was well tolerated by all
> patients. No major adverse reactions were noted. CONCLUSIONS:: These
> data suggest that multi antioxidative treatment in chronic HCV patients
> is well tolerated and may have a beneficial effect on
> necro-inflammatory variables. A combination of antiviral and
> antioxidative therapies may enhance the overall response rate of these
> patients.
>
> PMID: 16082287 [PubMed - as supplied by publisher]
>
> --------------------------------------------------------------------------------
>
> Who loves ya.
> Tom
>
> Jesus Was A Vegetarian!
> http://jesuswasavegetarian.7h.com
> Man Is A Herbivore!
> http://pages.ivillage.com/ironjustice/manisaherbivore
> DEAD PEOPLE WALKING
> http://pages.ivillage.com/ironjustice/deadpeoplewalking
>
> --------------------------------------------------------------------------------
| |
| Sbharris[atsign]ix.netcom.com 2005-08-09, 5:58 pm |
| ironjustice@aol.com wrote:
> J Clin Gastroenterol. 2005 Sep;39(8):737-742. Related Articles, Links
>
>
> Treatment of Chronic Hepatitis C Virus Infection via Antioxidants:
> Results of a Phase I Clinical Trial.
>
> Melhem A, Stern M, Shibolet O, Israeli E, Ackerman Z, Pappo O, Hemed N,
> Rowe M, Ohana H, Zabrecky G, Cohen R, Ilan Y.
>
> Pathology, Hebrew University, Hadassah Medical Center, Jerusalem,
> Israel; and double daggerMarcus Foundation, Atlanta, GA.
CONCLUSIONS::
These
> data suggest that multi antioxidative treatment in chronic HCV patients
> is well tolerated and may have a beneficial effect on
> necro-inflammatory variables.
COMMENT:
Hep C does change over time, and viral load levels do drop
spontaneously in some patients. It has a lot more spontaneous
remissions than cancer, that's for sure.
Thus, a treatment study such as the above BADLY needs a control group
of some kind. It's not there. None of the results seen are so far out
of the ordinary that it's impossible to believe they are not the result
of the treatments proferred. In the abstract, they don't even attempt
to use case controls or a *historical* control group. Lousy science.
SBH
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| Mortimer Schnerd, RN 2005-08-09, 5:58 pm |
| outrider wrote:[vbcol=seagreen]
> Thanks Tom. Zee
>
>
>
> ironjustice@aol.com wrote:
How about taking this cross posted shit and shoving it where the sun doesn't
shine? We don't want it in sci.med.nursing. As a matter of fact, we don't want
any crossposted shit at all.
Have a nice day,
--
Mortimer Schnerd, RN
mschnerd@carolina.rr.com.REMOVE
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| Waterspider 2005-08-10, 5:57 pm |
|
"Sbharris[atsign]ix.netcom.com" <sbharris@ix.netcom.com> wrote in message
news:1123623512.942840.87340@z14g2000cwz.googlegroups.com...
> ironjustice@aol.com wrote:
> CONCLUSIONS::
> These
>
> COMMENT:
> Hep C does change over time, and viral load levels do drop
> spontaneously in some patients. It has a lot more spontaneous
> remissions than cancer, that's for sure.
There is no such thing as "spontaneous remission" or any other kind of
remission in hepatitis c. Symptoms may come and go and viral load may vary,
but the virus remains, continues to replicate and continues to destroy liver
cells as it does so. Comparing hep c (a viral disease) with cancer (not a
viral disease) is pointless.
Waterspider
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"Waterspider" <waterspider@moonshine.net> wrote in message
news:a%sKe.194311$tt5.155468@edtnps90...
>
> "Sbharris[atsign]ix.netcom.com" <sbharris@ix.netcom.com> wrote in message
> news:1123623512.942840.87340@z14g2000cwz.googlegroups.com...
>
> There is no such thing as "spontaneous remission" or any other kind of
> remission in hepatitis c. Symptoms may come and go and viral load may
vary,
> but the virus remains, continues to replicate and continues to destroy
liver
> cells as it does so. Comparing hep c (a viral disease) with cancer (not a
> viral disease) is pointless.
>
Actually, there are some cases where the viral load has disappeared, even in
patients who have been infected for years--very rare, but not unheard of.
Lana
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| eileen 2005-08-11, 10:55 pm |
|
szozu wrote:
> Actually, there are some cases where the viral load has disappeared, even in
> patients who have been infected for years--very rare, but not unheard of.
>
> Lana
How you doing Lana?, long time no talky!
eileen
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