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Home > Archive > Hepatitis disease > July 2005 > Interferon / medical bloodletting .. ?
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Interferon / medical bloodletting .. ?
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| ironjustice@aol.com 2005-06-27, 10:00 am |
| So since the .. mode of operation of interferon seems to be ..
suppression of red blood cell production .. therefore .. decreased
blood cell .. mass .. equivalent .. to .. bloodletting / venesection /
phlebotomy .. ?
http://www.hubmed.org/display.cgi?i...uids=3D15951552
Suppression of haematopoiesis during therapy of chronic hepatitis C
with different interferon {alpha} mono and combination therapy
regimens.
Schmid M, Kreil A, Jessner W, Homoncik M, Datz C, Gangl A, Ferenci P,
Peck-Radosavljevic M
Gut. 2005 Jul ; 54(7): 1014-20
BACKGROUND: Treatment of chronic hepatitis C with interferon
(IFN)-alpha and ribavirin has haematotoxic effects. We evaluated the
effects of four different IFN/IFN-ribavirin treatment regimens on
haematopoiesis. METHODS: Haematopoiesis was studied in 133 patients
with chronic hepatitis C receiving IFN-alpha2b alone (group A) or in
combination with ribavirin (group B), pegylated IFN-alpha2a (group C),
or pegylated IFN-alpha2b (group D) in combination with ribavirin.
RESULTS: At week 4, haemoglobin levels were diminished in all groups
receiving combination therapy. In the monotherapy group, haemoglobin
decreased slightly after eight weeks. In all groups, haemoglobin
remained diminished throughout therapy. In all patients, leucocytes
(while blood cells) decreased after four weeks and remained low during
treatment. Platelets (peripheral platelet count (PPC)) were decreased
in all groups after four weeks and remained below baseline levels
during therapy in group A, C, and D whereas in group B PPC recovered
early and reached baseline levels at week 16 of therapy. Concomitantly
with the decreases in haemoglobin and PPC, erythropoietin increased in
all groups receiving combination therapy and thrombopoietin in all
groups. Patients treated with pegylated IFN-alpha2a and those who
received pegylated IFN-alpha2b combination therapy differed only in
leucopoiesis, whereas erythropoiesis and thrombopoiesis were
comparable. CONCLUSION: IFN-alpha based therapies are associated with a
decrease in all three haematopoietic lineages, irrespective of the type
of therapy used. The stronger suppressive effect of pegylated
IFN-alpha2a on leucopoiesis could be due to a dose effect. Overall,
concentrations of endogenous haematopoietic growth factors are
increased but can only partially alleviate haematotoxicity. Potential
uses of exogenous haematopoietic growth factors and their impact on the
virological response need to be explored.
Abstract =B7 PubMed =B7 FullText =B7 SFX =B7 LF+ =B7 GS =B7 Order =B7 Clip =
=B7
Citation =B7 BibTeX =B7 Related =B7 TouchGraph =B7 Scopus =B7 References =
=B7
Tag
tags: annotation:
Haematopoiesis
<haematology> The formation and development of blood cells involving
both proliferation and differentiation from stem cells. In adult
mammals usually occurs in bone marrow.
http://cancerweb.ncl.ac.uk/cgi-bin/...&action=3DSear=
ch+OMD
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.=ADcom
Man Is A Herbivore!
http://pages.ivillage.com/iron=ADju...manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/iron=ADju...adpeoplewalking
| |
| Waterspider 2005-06-27, 10:00 am |
|
<ironjustice@aol.com> wrote in message
news:1119801968.705896.291170@g49g2000cwa.googlegroups.com...
So since the .. mode of operation of interferon seems to be ..
suppression of red blood cell production .. therefore .. decreased
blood cell .. mass .. equivalent .. to .. bloodletting / venesection /
phlebotomy .. ?
Tom, you're just getting silly now.
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| Manky Badger 2005-06-27, 5:54 pm |
|
"Waterspider" <waterspider@moonshine.net> wrote in message
news:eqGve.77629$HI.74997@edtnps84...
>
> <ironjustice@aol.com> wrote in message
> news:1119801968.705896.291170@g49g2000cwa.googlegroups.com...
> So since the .. mode of operation of interferon seems to be ..
> suppression of red blood cell production .. therefore .. decreased
> blood cell .. mass .. equivalent .. to .. bloodletting / venesection /
> phlebotomy .. ?
>
>
> Tom, you're just getting silly now.
You've got to hand it to him, though - he's kept it going all this time ;o)
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| Waterspider 2005-06-27, 5:54 pm |
|
<ironjustice@aol.com> wrote in message
news:1119866445.097545.250180@f14g2000cwb.googlegroups.com...
> Result of bloodletting .. fewer red blood cells ..
> Result of medical intervention / interferon .. fewer red blood cells ..
>
> Who loves ya.
> Tom
I hate to encourage this, but decreasing the number of red blood cells does
not kill HCV.
Waterspider
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| "Potential uses of exogenous haematopoietic growth factors and their impact
on the
virological response need to be explored."
I think you're jumping to conclusions.
<ironjustice@aol.com> wrote in message
news:1119801968.705896.291170@g49g2000cwa.googlegroups.com...
So since the .. mode of operation of interferon seems to be ..
suppression of red blood cell production .. therefore .. decreased
blood cell .. mass .. equivalent .. to .. bloodletting / venesection /
phlebotomy .. ?
http://www.hubmed.org/display.cgi?i...9&uids=15951552
Suppression of haematopoiesis during therapy of chronic hepatitis C
with different interferon {alpha} mono and combination therapy
regimens.
Schmid M, Kreil A, Jessner W, Homoncik M, Datz C, Gangl A, Ferenci P,
Peck-Radosavljevic M
Gut. 2005 Jul ; 54(7): 1014-20
BACKGROUND: Treatment of chronic hepatitis C with interferon
(IFN)-alpha and ribavirin has haematotoxic effects. We evaluated the
effects of four different IFN/IFN-ribavirin treatment regimens on
haematopoiesis. METHODS: Haematopoiesis was studied in 133 patients
with chronic hepatitis C receiving IFN-alpha2b alone (group A) or in
combination with ribavirin (group B), pegylated IFN-alpha2a (group C),
or pegylated IFN-alpha2b (group D) in combination with ribavirin.
RESULTS: At week 4, haemoglobin levels were diminished in all groups
receiving combination therapy. In the monotherapy group, haemoglobin
decreased slightly after eight weeks. In all groups, haemoglobin
remained diminished throughout therapy. In all patients, leucocytes
(while blood cells) decreased after four weeks and remained low during
treatment. Platelets (peripheral platelet count (PPC)) were decreased
in all groups after four weeks and remained below baseline levels
during therapy in group A, C, and D whereas in group B PPC recovered
early and reached baseline levels at week 16 of therapy. Concomitantly
with the decreases in haemoglobin and PPC, erythropoietin increased in
all groups receiving combination therapy and thrombopoietin in all
groups. Patients treated with pegylated IFN-alpha2a and those who
received pegylated IFN-alpha2b combination therapy differed only in
leucopoiesis, whereas erythropoiesis and thrombopoiesis were
comparable. CONCLUSION: IFN-alpha based therapies are associated with a
decrease in all three haematopoietic lineages, irrespective of the type
of therapy used. The stronger suppressive effect of pegylated
IFN-alpha2a on leucopoiesis could be due to a dose effect. Overall,
concentrations of endogenous haematopoietic growth factors are
increased but can only partially alleviate haematotoxicity. Potential
uses of exogenous haematopoietic growth factors and their impact on the
virological response need to be explored.
Abstract · PubMed · FullText · SFX · LF+ · GS · Order · Clip ·
Citation · BibTeX · Related · TouchGraph · Scopus · References ·
Tag
tags: annotation:
Haematopoiesis
<haematology> The formation and development of blood cells involving
both proliferation and differentiation from stem cells. In adult
mammals usually occurs in bone marrow.
http://cancerweb.ncl.ac.uk/cgi-bin/...tion=Search+OMD
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h._com
Man Is A Herbivore!
http://pages.ivillage.com/iron_justice/manisaherbivore
DEAD PEOPLE WALKING
http://pages.ivillage.com/iron_just...adpeoplewalking
| |
| Waterspider 2005-07-03, 12:32 pm |
|
<ironjustice@aol.com> wrote in message
news:1119927706.309034.67900@g47g2000cwa.googlegroups.com...
> not kill HCV.
> Waterspider <
>
> http://tinyurl.com/d2mtz
> An .. "effective alternative to interferon" ..
>
Combo kills HCV, bloodletting doesn't. Soooo..... it's NOT an effective
alternative.
Someone undertaking bloodletting for hep C rather than medically accepted,
standard, interferon-based treatment could DIE from hep C related liver
disease, whereas they might have recovered (+60-80% odds that they would)
with combo.
Your comments are irresponsible and dangerous.
Waterspider
p.s. I do agree that iron overload can be a problem with hep C and other
liver disease, and that it should be addressed, but try not to lose sight of
the forest for that single damn tree.
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| Manky Badger 2005-07-03, 12:32 pm |
|
"Waterspider" <waterspider@moonshine.net> wrote in message
news:Zbhxe.110814$tt5.71263@edtnps90...
> p.s. I do agree that iron overload can be a problem with hep C and other
> liver disease, and that it should be addressed, but try not to lose sight
> of the forest for that single damn tree.
I think it's fair to say that no one's ever denied the seriousness of
genuine cases of iron overload.
However, your analogy has hit the nail square on the head.
It is foolish to deliberately invoke iron deficiency with all its attendent
problems in a misguided attempt to avoid iron overload. After all -
deficiency or overload - which do we find in the clinics and the labs the
most ?
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| Waterspider 2005-07-09, 12:15 pm |
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"Lord Cerne Abbas" <lordcerne@veloceraptor.free-online.co.u> wrote in
message news:42cb86e8$0$2899$ed2e19e4@ptn-nntp-reader04.plus.net...
> Waterspider wrote:
>
>
>
>
>
> He's been silly for the the eight years. That is so *Canadian* of you
> Waterspider.
> Lord Cerne Abbas
Yes, I know, but I'd hate to disappoint you, seeing as how I'm such a polite
and accommodating Canadian and all... <g>
Waterspider
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