Hepatitis disease - Liver disease / organ iron accumulation

Author

Liver disease / organ iron accumulation

ironjustice@aol.com

2005-05-25, 8:55 am

Liver Int. 2005 Jun;25(3):513-7. Links

Hepatic iron overload in alcoholic end-stage liver disease is
associated with iron deposition in other organs in the absence of HFE-1
hemochromatosis.

Eng SC, Taylor SL, Reyes V, Raaka S, Berger J, Kowdley KV.

Department of Medicine, university of Washington Medical Center
Seattle, WA, USA.

Eng SC, Taylor SL, Reyes V, Raaka S, Berger J, Kowdley KV. Hepatic iron
overload in alcoholic end-stage liver disease is associated with iron
deposition in other organs in the absence of HFE-1 hemochromatosis.
Liver International 2005: 25: 513-517. (c) Blackwell Munksgaard 2005
Abstract: Background: End-stage cirrhosis in the absence of hereditary
hemochromatosis (HHC) can be associated with moderate to marked hepatic
iron overload, especially in liver disease as a result of alcohol
and/or hepatitis C. However, no published studies have addressed
extrahepatic iron deposition in this setting. Method: A retrospective
case series from three autopsied patients who died from end-stage
cirrhosis associated with significant hepatic iron overload. Histology
of vital organs was performed to detect extrahepatic iron deposition.
HFE genotyping for the C282Y and H63D mutations was determined from
archival tissue. Hepatic iron index and hepatic iron concentration
(HIC) were quantified from formalin-fixed, paraffin-embedded tissue.
Medical records were reviewed for possible causes of iron overload.
Results: Two patients were H63D heterozygous (H63D +/-) and one was
wild type (C282Y -/-, H63D -/-). Histology revealed evidence of
stainable iron in the heart and pancreas of all three subjects.
Additionally, stainable iron was seen in the stomach in one subject and
in the thyroid, pituitary, choroid plexus and testes in another
subject. HIC ranged from 4354 to 6834 mug/g dry weight and HII from 1.8
to 2.2 (mumol/g/years). Conclusion: Iron overload secondary to
end-stage liver disease can be associated with iron deposition in other
organs in the absence of HFE-1 HHC.

PMID: 15910487 [PubMed - in process]

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Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
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DEAD PEOPLE WALKING
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Alan

2005-05-29, 5:53 pm

In article <1117028796.417310.92240@g14g2000cwa.googlegroups.com>,
ironjustice@aol.com () wrote:

> Who loves ya.
> Tom
> Jesus Was A Vegetarian!

Crap! He ate fish and gave it to his followers.

Hey, I have a song for you:

FAR AWAY EYES -M. Jagger/K. Richards)

I was driving home early sunday morning through bakersfield
Listening to gospel music on the colored radio station
And the preacher said, you know you always have the
Lord by your side

And I was so pleased to be informed of this that I ran
Twenty red lights in his honor
Thank you jesus, thank you lord

I had an arrangement to meet a girl, and I was kind of late
And I thought by the time I got there shed be off
Shed be off with the nearest truck driver she could find
Much to my surprise, there she was sittin in the corner
A little bleary, worse for wear and tear
Was a girl with far away eyes

So if youre down on your luck
And you cant harmonize
Find a girl with far away
And if youre downright disgusted
And life aint worth a dime
Get a girl with far away eyes

Well the preacher kept right on saying that all I had to do was send
Ten dollars to the church of the sacred bleeding heart of jesus
Located somewhere in los angeles, california
And next week theyd say my prayer on the radio
And all my dreams would come true
So I did, the next week, I got a prayer with a girl
Well, you know what kind of eyes she got

So if youre down on your luck
I know you all sympathize
Find a girl with far away eyes
And if youre downright disgusted
And life aint worth a dime
Get a girl with far away eyes

Firebird

http://www.veloceraptor.free-online.co.uk/masters.html