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Home > Archive > Hepatitis disease > May 2005 > Dietary intake of iron / hepatitis C
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Dietary intake of iron / hepatitis C
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| ironjustice@aol.com 2005-05-18, 11:21 am |
| <<snip>>
decreased dietary intake of iron may constitute an important adjuvant
therapy in patients with CH-C.
<<snip>>
Poster 341: EFFICACY OF LONG-TERM DIETARY IRON RESTRICTION IN PATIENTS
WITH CHRONIC HEPATITIS C
Kazuko Iwata, Mie university Hospital, Tsu City, Mie, Japan; Motoh
Iwasa, Masahiko Kaito, Masaki Takeo, Jiro Ikoma, Yukihiko Adachi, Mie
University School of Medicine, Tsu City, Mie, Japan.
Objectives
It is important to maintain reduced serum alanine aminotransferase
(ALT) levels in cases with chronic hepatitis C (CH-C) that do not
respond to interferon (IFN) and in those with no indication of IFN
therapy. We reported previously that dietary restriction of iron intake
reduces serum ALT levels in such patients. We evaluated CH-C patients
treated with iron-restricted diet for two or more consecutive years,
mainly focusing on the balance of energy intake, physical examination,
and changes in hematological indices of nutrition.
Methods
Twenty-two patients with CH-C (males, 18; females, 4; mean age, 56
year-old) that consulted our outpatient department were enrolled in
this study. The inclusion criteria were as follows: 1) elevation of ALT
levels above the upper normal limit for 3 months or more; 2) positive
tests for HCV-antibody and HCV-RNA; 3) absence of other causes of CH
(alcoholic liver disease, drug-induced liver injury, hemochromatosis)
and negativity for hepatitis B surface antigen and for serum
anti-nuclear and anti-mitochondrial autoantibodies. Twenty cases had
received IFN therapy for more than 12 months before the beginning of
the study; none of them responded to IFN therapy. Dietary prescriptions
included iron intake 7 mg/day or less, energy intake 30 kcal/kg/day,
protein intake 1.1-1.2 g/kg/day, and a fat energy fraction of 20%.
Nutritional balance was evaluated based on meal records, and
instructions was given when necessary.
Results
The average energy intake before dietary prescription was 2184 kcal
(36.7 kcal/kg)/day, and it was significantly reduced to 1655 kcal (28.5
kcal/kg)/day (p < 0.01), and then maintained stable at 30 kcal/kg/day.
The average protein intake before dietary prescription was 85.7 g (1.45
g/kg)/day and it was reduced to 1.1-1.2 g/kg/day after the
prescription. The average fat intake of 66.5 g (1.1 g/kg)/day and the
average fat energy fraction of 27% before the dietary prescription were
significantly decreased to 30.8 g (0.52 g/kg)/day; p < 0.01 and 16% (p
< 0.001), respectively, after dietary instructions. The fat energy
fraction was maintained at a level of 20% or less. Carbohydrate intake
did not change remarkably during the observation period, although the
carbohydrate energy fraction significantly (p < 0.001) increased. The
average iron intake decreased significantly (p < 0.001) from 9.6
(before) to 6.1, 5.2, 5.1, 5.2, and 5.1 mg/day 6, 12, 18, and 24 months
after dietary prescription, respectively. Body mass index (BMI) before
diet prescription was 23.9 on average; BMI had no significant change
throughout the course. The body fat percentage was 24.6% on average
before the diet instructions, and it significantly decreased after the
diet. The average values of aspartate aminotransferase and ALT before
diet prescription were 65 IU/l and 66 IU/l, respectively, and they were
significantly reduced to 48 IU/l and 49 IU/l, respectively, after 24
months (p < 0.01). Serum iron levels significantly decreased after 18
(p < 0.01) and 24 (p < 0.05) months, while unsaturated iron binding
capacity tended to increase. The average serum ferritin levels were
376, 210, 189, 189, 141 ng/ml before and 6, 12, 18, and 24 months after
diet, respectively; there was a significant reduction (p < 0.01) in the
values measured before and after the diet instructions. The average
levels of hemoglobin, albumin and cholinesterase did not change
significantly during the follow-up period.
Conclusions
Restriction of iron intake is safe and well tolerated for a long
period. The results of our present study suggest that decreased dietary
intake of iron may constitute an important adjuvant therapy in patients
with CH-C.
Who loves ya.
Tom
| |
| Mondino 2005-05-18, 11:21 am |
| Interesting. I understand the connection between iron and HC. What are the
best foods to avoid that are high in iron?
In article <1115584024.866020.225110@o13g2000cwo.googlegroups.com>,
ironjustice@aol.com says...
>
><<snip>>
>decreased dietary intake of iron may constitute an important adjuvant
>therapy in patients with CH-C.
><<snip>>
>
>Poster 341: EFFICACY OF LONG-TERM DIETARY IRON RESTRICTION IN
PATIENTS
>WITH CHRONIC HEPATITIS C
>
>Kazuko Iwata, Mie university Hospital, Tsu City, Mie, Japan; Motoh
>Iwasa, Masahiko Kaito, Masaki Takeo, Jiro Ikoma, Yukihiko Adachi, Mie
>University School of Medicine, Tsu City, Mie, Japan.
>
>Objectives
>It is important to maintain reduced serum alanine aminotransferase
>(ALT) levels in cases with chronic hepatitis C (CH-C) that do not
>respond to interferon (IFN) and in those with no indication of IFN
>therapy. We reported previously that dietary restriction of iron intake
>reduces serum ALT levels in such patients. We evaluated CH-C patients
>treated with iron-restricted diet for two or more consecutive years,
>mainly focusing on the balance of energy intake, physical examination,
>and changes in hematological indices of nutrition.
>
>Methods
>Twenty-two patients with CH-C (males, 18; females, 4; mean age, 56
>year-old) that consulted our outpatient department were enrolled in
>this study. The inclusion criteria were as follows: 1) elevation of ALT
>levels above the upper normal limit for 3 months or more; 2) positive
>tests for HCV-antibody and HCV-RNA; 3) absence of other causes of CH
>(alcoholic liver disease, drug-induced liver injury, hemochromatosis)
>and negativity for hepatitis B surface antigen and for serum
>anti-nuclear and anti-mitochondrial autoantibodies. Twenty cases had
>received IFN therapy for more than 12 months before the beginning of
>the study; none of them responded to IFN therapy. Dietary prescriptions
>included iron intake 7 mg/day or less, energy intake 30 kcal/kg/day,
>protein intake 1.1-1.2 g/kg/day, and a fat energy fraction of 20%.
>Nutritional balance was evaluated based on meal records, and
>instructions was given when necessary.
>
>Results
>The average energy intake before dietary prescription was 2184 kcal
>(36.7 kcal/kg)/day, and it was significantly reduced to 1655 kcal (28.5
>kcal/kg)/day (p < 0.01), and then maintained stable at 30 kcal/kg/day.
>The average protein intake before dietary prescription was 85.7 g (1.45
>g/kg)/day and it was reduced to 1.1-1.2 g/kg/day after the
>prescription. The average fat intake of 66.5 g (1.1 g/kg)/day and the
>average fat energy fraction of 27% before the dietary prescription were
>significantly decreased to 30.8 g (0.52 g/kg)/day; p < 0.01 and 16% (p
>< 0.001), respectively, after dietary instructions. The fat energy
>fraction was maintained at a level of 20% or less. Carbohydrate intake
>did not change remarkably during the observation period, although the
>carbohydrate energy fraction significantly (p < 0.001) increased. The
>average iron intake decreased significantly (p < 0.001) from 9.6
>(before) to 6.1, 5.2, 5.1, 5.2, and 5.1 mg/day 6, 12, 18, and 24 months
>after dietary prescription, respectively. Body mass index (BMI) before
>diet prescription was 23.9 on average; BMI had no significant change
>throughout the course. The body fat percentage was 24.6% on average
>before the diet instructions, and it significantly decreased after the
>diet. The average values of aspartate aminotransferase and ALT before
>diet prescription were 65 IU/l and 66 IU/l, respectively, and they were
>significantly reduced to 48 IU/l and 49 IU/l, respectively, after 24
>months (p < 0.01). Serum iron levels significantly decreased after 18
>(p < 0.01) and 24 (p < 0.05) months, while unsaturated iron binding
>capacity tended to increase. The average serum ferritin levels were
>376, 210, 189, 189, 141 ng/ml before and 6, 12, 18, and 24 months after
>diet, respectively; there was a significant reduction (p < 0.01) in the
>values measured before and after the diet instructions. The average
>levels of hemoglobin, albumin and cholinesterase did not change
>significantly during the follow-up period.
>
>Conclusions
>Restriction of iron intake is safe and well tolerated for a long
>period. The results of our present study suggest that decreased dietary
>intake of iron may constitute an important adjuvant therapy in patients
>with CH-C.
>
>Who loves ya.
>Tom
>
| |
| ironjustice@aol.com 2005-05-18, 11:21 am |
| I'm not sure .. WHAT .. the study diet .. was ..
I have no access to full text articles ..
The diet used in the study most likely would give one an idea ..
I know .. meat .. is .. ALL meat .. is ..
Who loves ya.
Tom
| |
| greyhackles 2005-05-18, 11:21 am |
| On 8 May 2005 17:42:38 -0700, "ironjustice@aol.com" <ironjustice@aol.com>
wrote:
>I'm not sure .. WHAT .. the study diet .. was ..
>
>I have no access to full text articles ..
>
>The diet used in the study most likely would give one an idea ..
>
>I know .. meat .. is .. ALL meat .. is ..
>
>Who loves ya.
>Tom
When was that study actually published? 2001?
| |
| Juhana Harju 2005-05-18, 11:21 am |
| greyhackles wrote:
:: On 8 May 2005 17:42:38 -0700, "ironjustice@aol.com"
:: <ironjustice@aol.com> wrote:
::: I know .. meat .. is .. ALL meat .. is ..
:: When was that study actually published? 2001?
Year 2004. Organ meats are highest in iron. Also red meat. Link to the
abstract:
http://www.ncbi.nlm.nih.gov/entrez/...t_uids=15043853
--
Juhana
| |
| Robert 2005-05-18, 11:22 am |
|
"Mondino" <mondino@verizon.com> wrote in message
news:g5qdnYcmMKtMMOPfRVn-uw@comcast.com...
> Interesting. I understand the connection between iron and HC. What are
the
> best foods to avoid that are high in iron?
I don't really think you do otherwise you wouldn't be asking that question.
HC is a genetic disease and there is a screen for the gene available right
now. If a family member has been diagnosed with HC then you should get the
test done. There are tests out there that can pick up HC.
You want to avoid foods high in iron without any evidence you have HC then
you don't understand what you have read.
People with HC need therapeutic interventions and not simply rely on diet.
Other disorders associated with iron overload need to get the condition
under control and therapeutic interventions done.
Iron deficiency anemia is very common out there. It is common in children,
in women and in bleeding disorders.
>
>
>
> In article <1115584024.866020.225110@o13g2000cwo.googlegroups.com>,
> ironjustice@aol.com says...
> PATIENTS
>
| |
| Robert 2005-05-18, 11:22 am |
| DC that not familiar with your abbreviations.
"Robert" <Robertitsme@hotmail.com> wrote in message
news:R6Wdnet1w7Z2POLfRVn-1A@got.net...
>
> "Mondino" <mondino@verizon.com> wrote in message
> news:g5qdnYcmMKtMMOPfRVn-uw@comcast.com...
> the
>
> I don't really think you do otherwise you wouldn't be asking that
question.
> HC is a genetic disease and there is a screen for the gene available right
> now. If a family member has been diagnosed with HC then you should get the
> test done. There are tests out there that can pick up HC.
> You want to avoid foods high in iron without any evidence you have HC then
> you don't understand what you have read.
> People with HC need therapeutic interventions and not simply rely on diet.
> Other disorders associated with iron overload need to get the condition
> under control and therapeutic interventions done.
> Iron deficiency anemia is very common out there. It is common in children,
> in women and in bleeding disorders.
>
[vbcol=seagreen]
>
>
| |
| outrider 2005-05-18, 11:22 am |
|
Robert wrote:
> "Mondino" <mondino@verizon.com> wrote in message
> news:g5qdnYcmMKtMMOPfRVn-uw@comcast.com...
are[vbcol=seagreen]
> the
>
> I don't really think you do otherwise you wouldn't be asking that
question.
> HC is a genetic disease and there is a screen for the gene available
right
> now. If a family member has been diagnosed with HC then you should
get the
> test done. There are tests out there that can pick up HC.
> You want to avoid foods high in iron without any evidence you have HC
then
> you don't understand what you have read.
> People with HC need therapeutic interventions and not simply rely on
diet.
> Other disorders associated with iron overload need to get the
condition
> under control and therapeutic interventions done.
> Iron deficiency anemia is very common out there. It is common in
children,[vbcol=seagreen]
> in women and in bleeding disorders.
>
When did Hep C become a genetic disease?
Zee[vbcol=seagreen]
adjuvant[vbcol=seagreen]
Mie[vbcol=seagreen]
intake[vbcol=seagreen]
patients[vbcol=seagreen]
years,[vbcol=seagreen]
examination,[vbcol=seagreen]
in[vbcol=seagreen]
of ALT[vbcol=seagreen]
positive[vbcol=seagreen]
CH[vbcol=seagreen]
hemochromatosis)[vbcol=seagreen]
had[vbcol=seagreen]
of[vbcol=seagreen]
prescriptions[vbcol=seagreen]
kcal/kg/day,[vbcol=seagreen]
kcal[vbcol=seagreen]
(28.5[vbcol=seagreen]
kcal/kg/day.[vbcol=seagreen]
(1.45[vbcol=seagreen]
the[vbcol=seagreen]
were[vbcol=seagreen]
16% (p[vbcol=seagreen]
intake[vbcol=seagreen]
the[vbcol=seagreen]
The[vbcol=seagreen]
months[vbcol=seagreen]
before[vbcol=seagreen]
change[vbcol=seagreen]
average[vbcol=seagreen]
the[vbcol=seagreen]
before[vbcol=seagreen]
were[vbcol=seagreen]
24[vbcol=seagreen]
18[vbcol=seagreen]
binding[vbcol=seagreen]
were[vbcol=seagreen]
after[vbcol=seagreen]
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dietary[vbcol=seagreen]
patients[vbcol=seagreen]
| |
| Robert 2005-05-18, 11:22 am |
|
"outrider" <outrider@despammed.com> wrote in message
news:1115682000.871443.35490@o13g2000cwo.googlegroups.com...
>
> Robert wrote:
> are
> question.
> right
> get the
> then
> diet.
> condition
> children,
>
>
>
> When did Hep C become a genetic disease?
Your abbreviations are not normal abbreviations used in medicine. HCV
hepatitis C Virus.
Confusion, yes.
| |
| outrider 2005-05-18, 11:22 am |
|
Robert wrote:
> "outrider" <outrider@despammed.com> wrote in message
> news:1115682000.871443.35490@o13g2000cwo.googlegroups.com...
What[vbcol=seagreen]
available[vbcol=seagreen]
should[vbcol=seagreen]
have HC[vbcol=seagreen]
on[vbcol=seagreen]
> Your abbreviations are not normal abbreviations used in medicine. HCV
> hepatitis C Virus.
> Confusion, yes.
Are you referring to the virus known as Hepatitis C when you say "HC is
a genetic disease"?
If you are referring to Hepatitis C (Hep C or HCV) when you use the
term HC I repeat my question: when did Hepatitis C become genetic?
IronJustice made the initial post. His reference was to Hepatitis C
Virus, variously known as HCV, or Hep C.
Whatever we call it, it is not called genetic.
Please clarify.
Zee
| |
| Twittering One 2005-05-18, 11:22 am |
| Clandestine code?
Fun, one thing,
Malfesance, another.
| |
| Robert 2005-05-18, 11:22 am |
|
"outrider" <outrider@despammed.com> wrote in message
news:1115757186.251307.72060@f14g2000cwb.googlegroups.com...
>
> Robert wrote:
> What
> available
> should
> have HC
> on
>
>
>
> Are you referring to the virus known as Hepatitis C when you say "HC is
> a genetic disease"?
>
> If you are referring to Hepatitis C (Hep C or HCV) when you use the
> term HC I repeat my question: when did Hepatitis C become genetic?
>
> IronJustice made the initial post. His reference was to Hepatitis C
> Virus, variously known as HCV, or Hep C.
>
> Whatever we call it, it is not called genetic.
>
> Please clarify.
>
> Zee
>
You can call it what ever you want and cause confusion if you like. The
original article mentioned CHC.
I was referring to HHC or HC as some call it.
I hope that clarifies it.
| |
| Robert 2005-05-18, 11:22 am |
|
"Twittering One" <twitteringone@aol.com> wrote in message
news:1115767861.179167.316320@o13g2000cwo.googlegroups.com...
> Clandestine code?
>
> Fun, one thing,
> Malfesance, another.
>
The yellow pumpkin disease YPD is another
| |
| TwitteringOne 2005-05-18, 11:22 am |
| Huh ~ ?
Sobriety on the job, essential.
Distorted judgement?
Unacceptable.
Simple enough issue.
| |
| ironjustice@aol.com 2005-05-18, 11:22 am |
| HHC - hereditary hemochromatosis
HC - hemochromatosis .. sometimes rererred AS .. 'genetic' ..
hemochromatosis .. BUT .. normally .. HHC .. refers to the genetic ..
and HC .. simply .. iron overload / secondary / acquired iron overload
with NO genetic factors ..
Who loves ya.
Tom
| |
| Robert 2005-05-18, 11:22 am |
|
"outrider" <outrider@despammed.com> wrote in message
news:1115682000.871443.35490@o13g2000cwo.googlegroups.com...
>
> Robert wrote:
> are
> question.
> right
> get the
> then
> diet.
> condition
> children,
>
>
>
> When did Hep C become a genetic disease?
Your abbreviations are not normal abbreviations used in medicine. HCV
hepatitis C Virus.
Confusion, yes.
|
| |
|
|