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Home > Archive > Hepatitis disease > May 2005 > Chronic iron overload and toxicity: Clinical chemistry perspective
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Chronic iron overload and toxicity: Clinical chemistry perspective
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| ironjustice@aol.com 2005-05-06, 12:00 pm |
| http://www.findarticles.com/p/artic...107/ai_n9001606
http://tinyurl.com/787m4
Chronic iron overload and toxicity: Clinical chemistry perspective
Clinical Laboratory Science, Summer 2001 by Kang, Jae O
FOCUS: IRON OVERLOAD
The content of body iron is regulated primarily by absorption since
humans have no physiological mechanism by which excess iron is
excreted. This regulation, however, is not absolute. Many factors such
as the content of diets, iron doses, life styles, etc. influence iron
absorption. In the past, nutrition programs for iron fortification and
the ingestion of iron preparations have been widely practiced because
of the seriousness of worldwide iron deficiency. Also, we now know that
a significant number of asymptomatic people carry the hemochromatosis
gene, HFE, indicating that these people have the potential to
accumulate excess body iron in their lifetime. Excess body iron can be
highly toxic. This toxicity involves many organs leading to a variety
of serious diseases such as liver disease, heart disease, diabetes
mellitus, hormonal abnormalities, dysfunctional immune system, etc. The
tissue damage associated with iron overload is believed to result
primarily from free radical reactions mediated by iron. Iron is an
effective catalyst in free radical reactions. The diseases associated
with iron overload can be managed effectively or prevented. Therefore,
early diagnosis of iron overload and appropriate therapy are critical.
By providing the necessary laboratory data, clinical chemistry
laboratories can play the pivotal role in the management of these
health problems.
INDEX TERMS: clinical chemistry laboratories; diagnosis; free radical
reactions; hemochromatosis; iron overload; iron toxicity.
Clin Lab Sci 2001; 14(3):209
LEARNING OBJECTIVES
1 . Describe the regulation of iron absorption.
2. List the three primary causes of iron overload.
3. Describe various chronic diseases associated with secondary iron
overload and the mechanisms involved.
4. Contrast the absorption process for heme iron with that for non-heme
iron.
5. List compounds in the diet that inhibit iron absorption and those
that enhance iron absorption.
6. List the organs most frequently damaged by hemachromatosis.
7. Identify the clinical chemistry laboratory procedures that would
detect damage to each of the organs most frequently damaged by
hemachromatosis.
8. Discuss the biochemical theories most often proposed to explain the
mechanisms that cause tissue damage due to excess iron.
Who loves ya.
Tom
Jesus Was A Vegetarian! http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
http://pages.ivillage.com/ironjustice/manisaherbivore
DEAD PEOPLE WALKING
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| Michael 2005-05-06, 12:00 pm |
| ironjustice@aol.com wrote:
> http://www.findarticles.com/p/artic...107/ai_n9001606
>
> http://tinyurl.com/787m4
>
> Chronic iron overload and toxicity: Clinical chemistry perspective
> Clinical Laboratory Science, Summer 2001 by Kang, Jae O
>
>
> FOCUS: IRON OVERLOAD
INDEX TERMS: clinical chemistry laboratories; diagnosis; free radical
reactions; hemochromatosis; iron overload; iron toxicity.
I don't see "multiple sclerosis" in that list anywhere.
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