| ironjustice@aol.com 2005-07-20, 2:03 pm |
| Muscle Nerve. 2005 Jul 15; [Epub ahead of print] Related Articles,
Links
Effects of N-acetylcysteine on glutathione oxidation and fatigue during
handgrip exercise.
Matuszczak Y, Farid M, Jones J, Lansdowne S, Smith MA, Taylor AA, Reid
MB.
Department of Physiology, university of Kentucky Medical Center, 800
Rose Street, Room MS-509, Lexington, Kentucky 40536-0298, USA.
Fatigue of hand and forearm muscle groups can limit task performance by
astronauts wearing space suits. Countermeasures to delay fatigue would
therefore be useful to the space program. N-acetylcysteine (NAC) has
been shown to inhibit fatigue during other tasks so we tested its
effects during handgrip exercise. Volunteers practiced isometric
handgrip maneuvers until performance was reproducible over three
successive sessions (baseline). Performance then was retested after
ingesting NAC (150 mg.kg(-1)) or saline. Drug administration increased
NAC and cysteine blood levels (P < 0.001). Performance of sustained
maximal efforts was unaffected. During repetitive submaximal efforts,
NAC delayed fatigue (130% baseline) and inhibited glutathione
oxidation. Saline did not alter glutathione status or performance of
sustained maneuvers; repetitive task performance was increased by 15%
(P < 0.05), a placebo effect. These data indicate that NAC supports
glutathione homeostasis in exercising humans and may delay muscle
fatigue during repetitive handgrip exercise. Our findings support
oxidative stress as a causal factor in human muscle fatigue and argue
for larger translational studies to define NAC effects on human
performance. Muscle Nerve, 2005.
PMID: 16025522 [PubMed - as supplied by publisher]
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