| ironjustice@aol.com 2005-11-26, 10:57 am |
| 1: Curr Med Chem. 2005;12(23):2711-29. Related Articles, Links
Molecular mechanisms of iron uptake by cells and the use of iron
chelators for the treatment of cancer.
Richardson DR.
Iron Metabolism and Chelation Program, Children's Cancer Institute
Australia for Medical Research, PO Box 81, High St, Randwick, Sydney,
NSW, 2031, Australia. d.richardson@ccia.org.au.
The field of iron (Fe) metabolism has been invigorated in the past 10
years with the discovery of a variety of new molecules involved in the
homeostatic control of this critical nutrient. These proteins include
the transferrin receptor 2, frataxin, hephaestin, hepcidin, hemojuvelin
and others. Basic understanding of the metabolism of Fe in cells is
vital in order to develop Fe chelators for the treatment of a variety
of disease states. In addition, examination of the role of Fe in the
regulation of cell cycle progression and angiogenesis has led to
investigations of the use of novel Fe chelators as anti-proliferative
agents. These studies have resulted in the identification of new
ligands that show selective and potent anti-tumor activity in vitro and
in vivo. Moreover, the ability of these chelators to inhibit growth is
not only limited to the inhibition of DNA synthesis. In fact, there is
a range of targets that are affected by Fe-depletion, such as molecules
involved in cell cycle control, angiogenesis and metastasis
suppression. These include hypoxia-inducible factor-1alpha
(HIF-1alpha), vascular endothelial growth factor-1 (VEGF1),
p21(CIP1/WAF1), cyclin D1 and the protein product of the N-myc
downstream regulated gene-1 (Ndrg1). As such, Fe chelators can now be
designed to target molecules to induce specific effects, for instance,
angiogenesis or metastasis suppression.
PMID: 16305467 [PubMed - in process]
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Ihttp://tinyurl.com/c5far
<<snip>>
paralysis was reversed
<<snip>>
n one test, the food of the mice was laced with doses of synthetic
tryptophan byproducts. After eating that food, the mice's
disease-related paralysis was reversed, the researchers report.
<<snip>>
"fewer relapses and less severe disease"
<<snip>>
In another test, mice had "fewer relapses and less severe disease"
after eating the experimental food, the researchers write.
<<snip>>
ordered the mice's out-of-control immune
system to calm down
<<snip>>
Basically, the byproducts ordered the mice's out-of-control immune
system to calm down. They did that by boosting chemicals that regulate
the immune system. That blocked the mice's disease from launching a
dangerous cascade of T cells.
Who loves ya.
Tom
Jesus Was A Vegetarian!
http://jesuswasavegetarian.7h.com
Man Is A Herbivore!
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DEAD PEOPLE WALKING
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