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Home > Archive > Multiple sclerosis support > April 2005 > Neurodegenerative diseases / iron-chelating drugs
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Neurodegenerative diseases / iron-chelating drugs
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| ironjustice@aol.com 2005-04-28, 11:51 am |
| Brain Res Brain Res Rev. 2005 Apr;48(2):379-87. Related Articles, Links
Mechanism of neuroprotective action of the anti-Parkinson drug
rasagiline and its derivatives.
Mandel S, Weinreb O, Amit T, Youdim MB.
Eve Topf and NPF Centers of Excellence for Neurodegenerative Diseases
Research, Israel; Department of Pharmacology, Rappaport Family Faculty
of Medicine Technion, Haifa, Israel.
The mitochondria are directly involved in cell survival and death.
Drugs that protect mitochondria viability and prevent apoptotic cascade
mechanisms involved in mitochondrial permeability transition pore
(MPTp) will be cytoprotective. Rasagiline (N-propargyl-1R-aminoindan)
is a novel, highly potent irreversible monoamine oxidase (MAO) B
inhibitor, anti-Parkinson drug. Unlike selegiline, rasagiline is not
derived from amphetamine, is not metabolized to neurotoxic
l-methamphetamine derivative, nor does it have sympathomimetic
activity. Rasagiline is effective as monotherapy or adjunct to L-dopa
for patients with early and late Parkinson's disease (PD), and adverse
events do not occur with greater frequency in subjects receiving
rasagiline than those on placebo. Controlled studies indicate that it
might have a disease-modifying effect in PD that may be related to
neuroprotection. Its S-isomer, TVP1022, is a relatively inactive MAO
inhibitor. However, both drugs have similar neuroprotective activities
in neuronal cell cultures in response to various neurotoxins and in
vivo (global ischemia, neurotrauma, head injury, anoxia, etc.),
indicating that MAO inhibition is not a pre-requisite for
neuroprotection. Structure activity studies have shown that the
neuroprotective activity is associated with the propargyl moiety of
rasagiline which protects mitochondrial viability and MPTp by
activating Bcl-2 and protein kinase C (PKC), and down regulating
pro-apoptotic FAS and Bax. Rasagiline and its derivatives also process
amyloid precursor protein (APP) to the neuroprotective-neurotrophic
soluble APP alpha (sAPPalpha) by PKC and MAP kinase-dependent
activation of alpha-secretase. The neuroprotective activity of
propargylamine has led us to develop novel bifunctional neuroprotective
iron-chelating MAO-inhibiting drugs possessing propargyl moiety for the
treatment of other neurodegenerative diseases.
PMID: 15850677 [PubMed - in process]
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| Jim Carter 2005-04-28, 5:51 pm |
| You are seeing this message because Tom Hennessy
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group then please understand that he appears to get
his thrills from the misfortunes of other people,
evidenced by his comments to the victims of forest
fires, the passing of members of this newsgroup and
his presence on all support newsgroups.
In keeping with his personality, Tommy believes
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using off-colour language and name calling
that would make a rattlesnake spew. This personality
trait is shown here:
http://flyembie.notlong.com
He seems to believe that whoever swears loudest and
longest is the winner.
In his mind, Hennessy believes he is a great
researcher who has won a Nobel Prize. In fact, he
merely copies medical material from the web and
pastes it to usenet, proudly calling this his research.
There was a time when people like Tommy were
institutionalized, now they are allowed to run for
public office and post to usenet. He is a fine
example why a mental health unit should not
obtain an internet account.
Previous addresses include watchman@nucleus.com,
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