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Home > Archive > Multiple sclerosis support > December 2005 > Spinal cord regeneration / iron chelators
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Spinal cord regeneration / iron chelators
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| ironjustice@aol.com 2005-12-22, 10:59 am |
| 1: Eur J Neurosci. 2005 Dec;22(12):3047-58. Related Articles, Links
Suppression of fibrous scarring in spinal cord injury of rat promotes
long-distance regeneration of corticospinal tract axons, rescue of
primary motoneurons in somatosensory cortex and significant functional
recovery.
Klapka N, Hermanns S, Straten G, Masanneck C, Duis S, Hamers FP, Muller
D, Zuschratter W, Muller HW.
Molecular Neurobiology Laboratory, Department of Neurology,
Heinrich-Heine-University, Moorenstrasse 5, D-40225 Dusseldorf,
Germany.
Abstract Traumatic injury of the central nervous system results in
formation of a collagenous basement membrane-rich fibrous scar in the
lesion centre. Due to accumulation of numerous axon-growth inhibitory
molecules the lesion scar is considered a major impediment for axon
regeneration. Following transection of the dorsal corticospinal tract
(CST) at thoracic level 8 in adult rats, transient suppression of
collagenous scarring in the lesion zone by local application of a
potent iron chelator and cyclic adenosine monophosphate resulted in the
delay of fibrous scarring. Treated animals displayed long-distance
growth of CST axons through the lesion area extending for up to 1.5-2
cm into the distal cord. In addition, the treatment showed a strong
neuroprotective effect, rescuing cortical motoneurons projecting into
the CST that normally die (30%) after thoracic axotomy. Further,
anterogradely traced CST axons regenerated through both grey and white
matter and developed terminal arborizations in grey matter regions. In
contrast to controls, injured animals receiving treatment showed
significant functional recovery in the open field, in the horizontal
ladder and in CatWalk locomotor tasks. We conclude that the fibrous
lesion scar plays a pivotal role as a growth barrier for regenerating
axons in adult spinal cord and that a delay in fibrotic scarring by
local inhibition of collagen biosynthesis and basement membrane
deposition is a promising and unique therapeutic strategy for treating
human spinal trauma.
PMID: 16367771 [PubMed - in process]
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| Joan Carter 2005-12-22, 10:59 am |
| On 22 Dec 2005 07:02:17 -0800, "ironjustice@aol.com" <ironjustice@aol.com> wrote
in alt.support.mult-sclerosis:
more cut and paste. I've heard that soaking your head in a pail of whitewash
helps reduce the iron in your body, Turdboy. Why don't you try it, say for a
couple of hours, and report back to us? That would be individual personal
research and mean so much more to us than the cut and paste stuff you do. I'm
not sure if breathing is affected by the soaking, perhaps you could tell us that
too.
---
Joan
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| Joan;
>I'm
>not sure if breathing is affected by the soaking, perhaps you could tell us that
>too.
Wouldn't matter if it were; he doesn't have much of a brain to damage
with oxygen deprivation. . .
Sylvia
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