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Home > Archive > Multiple sclerosis support > December 2005 > Atherosclerosis and neurodegenerative diseases / nontransferrin-bound iron
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Atherosclerosis and neurodegenerative diseases / nontransferrin-bound iron
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| ironjustice@aol.com 2005-12-22, 10:59 am |
| 1: FASEB J. 2005 Dec 20; [Epub ahead of print] Related Articles, Links
Endothelial activation and induction of monocyte adhesion by
nontransferrin-bound iron present in human sera.
Kartikasari AE, Georgiou NA, Visseren FL, van Kats-Renaud H, Sweder van
Asbeck B, Marx JJ.
Nontransferrin-bound iron (NTBI) has been detected in iron overload
diseases. This form of iron may exert pro-oxidant effects and modulate
cellular function and inflammatory response. The present study has
aimed to investigate the effects of serum NTBI on monocyte adherence to
endothelium. Measured by a recently developed high-throughput
fluorescence-based assay, serum NTBI was found to be higher in both
homozygotes of HFE C282Y mutation of hereditary hemochromatosis
(7.9+/-0.6 muM, n=9, P<0.001) and heterozygotes (4.0+/-0.5 muM, n=8,
P<0.001), compared with controls (1.6+/-0.2 muM, n=21). The effects of
these sera on monocyte adhesion and endothelial activation were
examined. Adhesion of normal human monocytes to C282Y homozygote- and
heterozygote-serum-treated human umbilical vein endothelial cells was
higher (25.0+/-0.9 and 22.1+/-0.7%, respectively) compared with
controls (17.6+/-0.5%, both P<0.001). For the three groups combined,
the expression of adhesion molecules, ICAM-1, VCAM-1, and E-selectin,
was positively correlated to NTBI levels but not to the inflammatory
marker C-reactive protein. Furthermore, accumulation of intracellular
labile iron and oxidative radicals within the cells due to NTBI was
evidenced. Finally, counteraction of NTBI-induced endothelial
activation was observed using iron chelators. These findings therefore
identify a physiological function of NTBI in monocyte-endothelial
interactions that may also contribute to the development of
atherosclerosis and neurodegenerative diseases.
PMID: 16368718 [PubMed - as supplied by publisher]
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| Joan Carter 2005-12-22, 10:59 am |
| On 22 Dec 2005 07:00:40 -0800, "ironjustice@aol.com" <ironjustice@aol.com> wrote
in alt.support.mult-sclerosis:
More cut and paste jobs.
Bah, humbug to you, Tinpot.
---
Joan
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