Psoriasis support - Curcumin ToPical quest

Author

Curcumin ToPical quest

randall

2006-07-21, 4:27 pm

Hi,

As i'm writing this i'm listening to a skin-zinc commercial on the
radio. lol

OK, so i E-mailed a link for psoria-gold to a friend today.

After looking at the info again it raised a few things i wasn't
tuned in to before.

I used a home brewed concoction of olive oil and curcumin back in
march/06 that
seemed to work fine but was itchy and messy. Plus I'm really more
concerned with
my IP6 trial that's been going on for a year now.

Can we get some folks here to experiment with psoria-gold? Or whip
up your own topical with curcumin in it?

http://psoriagold.com/site/

After looking at the article below and list of ingredients (site above)
i'm realizing now
that i didn't have anything in the mix to get the curcumin to penetrate
the
skin.

So, i may go back and do a trial with some ethanol or dmso added in.

Not sure if this article was posted previously. As most of us around
here have been eating the stuff, using it topically may be the key to
it.

http://www.dermatologytimes.com/der...l.jsp?id=178388

Los Angeles - Curcumin - the potent yellow spice found in turmeric
and curry powders - is effective in treating psoriasis as well as
many other skin conditions, according to Madalene Heng, M.D.

Dr. Heng, professor of medicine/dermatology at the university of
California, Los Angeles, School of Medicine, has developed curcumin
psoriasis and antiaging products sold under the names Psoria-Gold and
Re-Juven (OmniCure).

Results of a recent university of Texas study indicate that curcumin
effectively halts the growth of, and eventually kills, melanoma cells
in culture. Clinical trials also are under way to test the spice's
effects on colon cancer, pancreatic cancer, multiple myeloma and breast
cancer.

Dr. Heng has already incorporated curcumin treatment into her practice
as a treatment for all kinds of wounds, burns, sun-damaged skin,
psoriasis, eczema and other inflammatory skin conditions.

According to Dr. Heng, who has published many studies on the topic, it
makes sense that curcumin would work on psoriasis.

Psoriasis trigger

The trigger for psoriasis is an injurious stimulus, which may be a
wound, sunburn, allergic reaction or infection (bacterial, fungal or
viral). The injury stimulus, usually together with a superimposed
bacterial infection, triggers a wound healing response, leading to the
generation of T lymphocytes, which generates tumor necrosis
factor-alpha, new blood vessels, scar tissue and epidermal
proliferation. These healing processes require a source of energy -
namely, adenosine triphosphate, or ATP - which is generated from
glycogen stores in the cells by phosphorylase kinase, an enzyme
secreted five minutes after injury.

According to Dr. Heng, in normal non-psoriatic individuals, there is a
switch-off mechanism for phosphorylase kinase, and after the wound is
healed, phosphorylase kinase levels return to normal and the energy
supply to the inflammatory process is curtailed. This returns the skin
to normal except for some post-inflammatory changes such as erythema,
scarring and pigmentation.

In psoriatic individuals, the switch-off mechanism for phosphorylase
kinase is defective due to a defective Type II cAMP protein kinase
linked to a defective gene on the distal end of the 17th chromosome
(17q) (Tomfohrde J et al. Science 1994;264:1141-1145; Tournier S et al.
J Cell Physiol 1996; 167:196-203; Sozzi G et al. Genes Chromosomes
Cancer 1994;9:244-250). Increased phosphorylase kinase levels results
in increased phosphorylation reactions, leading to the increased
breakdown of glycogen stores to ATP, correlating with an increased
epidermal proliferation and psoriatic activity (Heng MCY et al. Br J
Dermatol 1994;130:298-306).

Curcumin's effect

"Curcumin, by lowering phosphorylase kinase levels in psoriatic
epidermis, has been shown to result in resolution of psoriasis, and
achieves this through decreasing the population of Ki-67 cells, i.e.,
cells capable of dividing, within the epidermis. (Heng MCY et al. Br J
Dermatol 2000;143:937-949)," she says. "While curcumin-untreated
psoriatic controls possess numerous Ki-67 cells, curcumin-treated
psoriatic epidermis possess few Ki-67 cells (Heng MCY et al. Br J
Dermatol 2000;143:937-949). The rapid epidermal turnover associated
with numerous Ki-67 cells results in generation of stratum corneum in
four days in untreated psoriatic controls, compared to 60 days in
curcumin-treated psoriatics, suggesting that a major defect in
psoriatic controls is loss of the epidermal barrier (resembling that of
a jellyfish), compared to curcumin-treated psoriatics.

"In our patients, when the epidermal barrier is completely reformed (as
shown by the skin appearance returning to normal), it has been observed
that all treatment (including curcumin) may be stopped without
recurrence of the psoriatic disease."

At this point, Dr. Heng says, there is plenty of preclinical anecdotal
evidence showing curcumin's benefits and that it is safe; clinical data
is now needed to make the spice a part of mainstream treatment.

------------------------------------------------------------------------------------------

Didn't Manfred post some links or sniPPets a week back from another
group?

No wonder I"m still thinking about it.

Let's see:
http://groups.google.com/groups/sea...sis&qt_s=Search

Oh ok. His thread was tumeric topically.

Has it started to penetrate my skin and brain yet? LOL

randall... doing the toPicals. GET the Curcumin!

manfred95@lycos.com

2006-07-22, 2:25 am

randall wrote:
> Hi,
>
> As i'm writing this i'm listening to a skin-zinc commercial on the
> radio. lol
>
>
> OK, so i E-mailed a link for psoria-gold to a friend today.
>
> After looking at the info again it raised a few things i wasn't
> tuned in to before.
>
> I used a home brewed concoction of olive oil and curcumin back in
> march/06 that
> seemed to work fine but was itchy and messy. Plus I'm really more
> concerned with
> my IP6 trial that's been going on for a year now.
>
> Can we get some folks here to experiment with psoria-gold? Or whip
> up your own topical with curcumin in it?
>
> http://psoriagold.com/site/
>
> After looking at the article below and list of ingredients (site above)
> i'm realizing now
> that i didn't have anything in the mix to get the curcumin to penetrate
> the
> skin.
>
> So, i may go back and do a trial with some ethanol or dmso added in.
>
> Not sure if this article was posted previously. As most of us around
> here have been eating the stuff, using it topically may be the key to
> it.

>
>
> http://www.dermatologytimes.com/der...l.jsp?id=178388
>
> Los Angeles - Curcumin - the potent yellow spice found in turmeric
> and curry powders - is effective in treating psoriasis as well as
> many other skin conditions, according to Madalene Heng, M.D.
>
> Dr. Heng, professor of medicine/dermatology at the university of
> California, Los Angeles, School of Medicine, has developed curcumin
> psoriasis and antiaging products sold under the names Psoria-Gold and
> Re-Juven (OmniCure).
>
> Results of a recent university of Texas study indicate that curcumin
> effectively halts the growth of, and eventually kills, melanoma cells
> in culture. Clinical trials also are under way to test the spice's
> effects on colon cancer, pancreatic cancer, multiple myeloma and breast
> cancer.
>
> Dr. Heng has already incorporated curcumin treatment into her practice
> as a treatment for all kinds of wounds, burns, sun-damaged skin,
> psoriasis, eczema and other inflammatory skin conditions.
>
> According to Dr. Heng, who has published many studies on the topic, it
> makes sense that curcumin would work on psoriasis.
>
> Psoriasis trigger
>
> The trigger for psoriasis is an injurious stimulus, which may be a
> wound, sunburn, allergic reaction or infection (bacterial, fungal or
> viral). The injury stimulus, usually together with a superimposed
> bacterial infection, triggers a wound healing response, leading to the
> generation of T lymphocytes, which generates tumor necrosis
> factor-alpha, new blood vessels, scar tissue and epidermal
> proliferation. These healing processes require a source of energy -
> namely, adenosine triphosphate, or ATP - which is generated from
> glycogen stores in the cells by phosphorylase kinase, an enzyme
> secreted five minutes after injury.
>
> According to Dr. Heng, in normal non-psoriatic individuals, there is a
> switch-off mechanism for phosphorylase kinase, and after the wound is
> healed, phosphorylase kinase levels return to normal and the energy
> supply to the inflammatory process is curtailed. This returns the skin
> to normal except for some post-inflammatory changes such as erythema,
> scarring and pigmentation.
>
> In psoriatic individuals, the switch-off mechanism for phosphorylase
> kinase is defective due to a defective Type II cAMP protein kinase
> linked to a defective gene on the distal end of the 17th chromosome
> (17q) (Tomfohrde J et al. Science 1994;264:1141-1145; Tournier S et al.
> J Cell Physiol 1996; 167:196-203; Sozzi G et al. Genes Chromosomes
> Cancer 1994;9:244-250). Increased phosphorylase kinase levels results
> in increased phosphorylation reactions, leading to the increased
> breakdown of glycogen stores to ATP, correlating with an increased
> epidermal proliferation and psoriatic activity (Heng MCY et al. Br J
> Dermatol 1994;130:298-306).
>
> Curcumin's effect
>
> "Curcumin, by lowering phosphorylase kinase levels in psoriatic
> epidermis, has been shown to result in resolution of psoriasis, and
> achieves this through decreasing the population of Ki-67 cells, i.e.,
> cells capable of dividing, within the epidermis. (Heng MCY et al. Br J
> Dermatol 2000;143:937-949)," she says. "While curcumin-untreated
> psoriatic controls possess numerous Ki-67 cells, curcumin-treated
> psoriatic epidermis possess few Ki-67 cells (Heng MCY et al. Br J
> Dermatol 2000;143:937-949). The rapid epidermal turnover associated
> with numerous Ki-67 cells results in generation of stratum corneum in
> four days in untreated psoriatic controls, compared to 60 days in
> curcumin-treated psoriatics, suggesting that a major defect in
> psoriatic controls is loss of the epidermal barrier (resembling that of
> a jellyfish), compared to curcumin-treated psoriatics.
>
> "In our patients, when the epidermal barrier is completely reformed (as
> shown by the skin appearance returning to normal), it has been observed
> that all treatment (including curcumin) may be stopped without
> recurrence of the psoriatic disease."
>
> At this point, Dr. Heng says, there is plenty of preclinical anecdotal
> evidence showing curcumin's benefits and that it is safe; clinical data
> is now needed to make the spice a part of mainstream treatment.
>
> ------------------------------------------------------------------------------------------
>
> Didn't Manfred post some links or sniPPets a week back from another
> group?
>
> No wonder I"m still thinking about it.
>
> Let's see:
> http://groups.google.com/groups/sea...sis&qt_s=Search
>
> Oh ok. His thread was tumeric topically.
>
> Has it started to penetrate my skin and brain yet? LOL
>
>
> randall... doing the toPicals. GET the Curcumin!

I have some curcumin capsules. I have found the powder inside mixes
well with glycerin. I was thinking of mixing the blend with some kind
of MSM cream what to ya think?
I don't have much P now as may derm has switched me from the cyclo to
Humira which I am using off label at this time. But I am still looking
for a more natural approach.

randall

2006-07-22, 4:24 pm

<sniP>
>
> I have some curcumin capsules. I have found the powder inside mixes
> well with glycerin. I was thinking of mixing the blend with some kind
> of MSM cream what to ya think?

Do you know if MSM absorbs and if that is a GOOD thing?

The whole idea I was trying to get across is when i used the
curcumin topically previously there wasn't any compound like ethanol
to further the absorption in to the skin.

And if you look at the list of ingredients in Dr. Heng's formula
you can see that she uses ethanol.

I supppose other things like DMSO would work, but at what
cost?

> I don't have much P now as may derm has switched me from the cyclo to
> Humira which I am using off label at this time. But I am still looking
> for a more natural approach.

OK. How about the glycerin, curcumin and grain alcohol?

NOT orally but topically. <g>

randall.. i suPPose you could drink it if your not bothered by more P!

manfred95@lycos.com

2006-07-23, 2:29 am

randall wrote:
>
> Do you know if MSM absorbs and if that is a GOOD thing?
>
> The whole idea I was trying to get across is when i used the
> curcumin topically previously there wasn't any compound like ethanol
> to further the absorption in to the skin.
>
> And if you look at the list of ingredients in Dr. Heng's formula
> you can see that she uses ethanol.
>
> I supppose other things like DMSO would work, but at what
> cost?
>
>
>
> OK. How about the glycerin, curcumin and grain alcohol?
>
>
> NOT orally but topically. <g>
>
> randall.. i suPPose you could drink it if your not bothered by more P!

According to at least one site, MSM does penetrate the skin but I have
not been able to substantiate that claim. Dr. Heng does suggest
rubbing the p (if the skin is not broken) with a little alcohol before
applying the Psoria-Gold. DMSO kinda scares me.

manfred95@lycos.com

2006-07-23, 2:29 am

>From the NPF forum again:
by GitOverIt

ok for turmeric gel recipe....

first though.....I urge anyone with P or PA to get a free consultation
from Dr. Heng.....

http://psoriainfo.org/site/index.php?id=31,0,0,1,0,0

the articles on the site explain much of the research that has been and
is being done....

I bought her Psoria-Gold gel but am going to try and make my
own...since it didn't last me as long as I thought it would........But
I must say...it was magical the way the poison
ivy-that-turned-to-psoriasis was cleared up in days!...I had poison ivy
on the under side of my fore arm...that included the top of my
hand...and a smaller amt on my left arm....I know I brought on the
koebner effect by scratching....I couldn't help it......it was so
itchy!
as it faded away with Caladryl-Clear....the P started showing it's
ugly, guttate self! only now it covered the whole arm from elbow down
on both sides....

so now I'm making my own...to early to tell how it is going....

agar agar ...a sea veggie can be purchased at the health store...a
little goes a long way I was told...directions on pkg.

aloe...gel or gel from plant...I never measure stuff...just wing it.

turmeric powder...either buy the powder or open capsules...I used about
6 to 8

alcohol...not much

I believe Dr. Hengs site lists the ingredients but I'm just keeping it
simple and not trying to duplicate it exactly.....

now if you want to add stuff here are some things you can try:

oregano
tea tree oil
glycerine (study done on this said was good for P)
lavendar, oil of
or any other fragrant oils

Irish moss is also used as a base for a gel...got mine at Indiana
Botanical Gardens...on line .............

you can also get many bulk herbs at:

http://www.herbalcom.com/store.php3...fb4980e6aab4b30

this homemade version I listed is not to be used by anyone opposed to
herbs....you are at your own risk!
not endorsed by anyone I know or the FDA
__________________
Sally

manfred95@lycos.com

2006-07-29, 9:24 pm

Again with NPF forum from gitoverit:
I did want to mention on the curcumin recipes to be sure and add
alcohol or Grapefruit seed extract as a preservative otherwise you may
get mold growing if not kept refridgerated and even then it won't last
as long...

anyone going to try it?

I mentioned in the thread on ALTERNATIVES the fact that I was using
SKIN MD over the curcumin gel...it is working so well I can't believe
how it acts as a shield keeping everything intact

http://www.psoriasis.org/forum/showthread.php?t=19572

manfred95@lycos.com

2006-07-29, 9:24 pm

manfred95@lycos.com

2006-07-29, 9:24 pm

manfred95@lycos.com wrote:
> Again with NPF forum from gitoverit:
> I did want to mention on the curcumin recipes to be sure and add
> alcohol or Grapefruit seed extract as a preservative otherwise you may
> get mold growing if not kept refridgerated and even then it won't last
> as long...
>
> anyone going to try it?
>
> I mentioned in the thread on ALTERNATIVES the fact that I was using
> SKIN MD over the curcumin gel...it is working so well I can't believe
> how it acts as a shield keeping everything intact
>
> http://wsomething to try!

--------------------------------------------------------------------------------
from GitOverIt:
i FOUND THE THREAD WHERE WE ALL DISCUSSED SKIN MD AND AN ARTICLE ON
SOME FINDINGS REGARDING USING A SHIELD FOR P...

http://www.psoriasis.org/forum/showthread.php?t=19572

It seems to tie in with Dr. Hengs articles and research into "the "skin
guard" area of defense from outside sources" invading the skin....When
I used her Psoria-Gold gel I noticed a very quick response in the skin
healing of the guttate....then I decided to make my own gel using
curcumin....it is a messy spice in that it turns everything yellow (Dr.
Hengs didn't) the sheets, skin, wherever I walked etc.. yellow bits of
curcumin dropping all over...
my first batch was made with Irish moss gel from a Botanical garden
near my home...I didn't like the texture...decided to try "agar" (sea
vegetable) it is clear, I like that better! Irish Moss was brown!
I did find that curcumin is grainy so when I made the second batch and
mixed it with "agar" I put it through a cheese cloth to filter out the
grains....

(If anyone is interested in my recipe I will post it)

In using it I wanted to make sure the mix did not rub off on sheets and
clothing, like the first batch did. (I put this on in the evening after
a long soak in hot tub or bathtub)

In pondering how to do this I remembered the SKIN MD that I had bought
to try on the poison ivy...it said it was a skin shield!
I tried it and it worked like a charm....in fact it only comes off
after soaking in the tub.....
__________________
SALLY
ww.psoriasis.org/forum/showthread.php?t=19572

randall

2006-07-30, 2:24 am

Hi Manfred,

I've been over to the NPF forum recently.

I didn't notice where sally said she was clear now.

She may be for all I know.

I am almost clear btw.

I can hardly wait to find out the connections between curcumin and
IP6, should there be any. The one thing i've not taken out of my
suPPlements.

My current trials has me backing out of all the suPPlements that
I figure arent't directly in the psoriasis pathways. I took out oral
curcumin
about six weeks back.

So far I'm on the correct path. Or the amount of sunshine (uvb plus
uva) i've received this
year made the difference.

And in other years i've had far more sun, it's easy to discount that.

So.

I can at this time only speculate based on my own trials and what
Dr. Heng has said and go from there.

Based on that i will do my own trials.

randall

manfred95@lycos.com wrote:
> manfred95@lycos.com wrote:
>
> --------------------------------------------------------------------------------
> from GitOverIt:
> i FOUND THE THREAD WHERE WE ALL DISCUSSED SKIN MD AND AN ARTICLE ON
> SOME FINDINGS REGARDING USING A SHIELD FOR P...
>
> http://www.psoriasis.org/forum/showthread.php?t=19572
>
>
> It seems to tie in with Dr. Hengs articles and research into "the "skin
> guard" area of defense from outside sources" invading the skin....When
> I used her Psoria-Gold gel I noticed a very quick response in the skin
> healing of the guttate....then I decided to make my own gel using
> curcumin....it is a messy spice in that it turns everything yellow (Dr.
> Hengs didn't) the sheets, skin, wherever I walked etc.. yellow bits of
> curcumin dropping all over...
> my first batch was made with Irish moss gel from a Botanical garden
> near my home...I didn't like the texture...decided to try "agar" (sea
> vegetable) it is clear, I like that better! Irish Moss was brown!
> I did find that curcumin is grainy so when I made the second batch and
> mixed it with "agar" I put it through a cheese cloth to filter out the
> grains....
>
> (If anyone is interested in my recipe I will post it)
>
> In using it I wanted to make sure the mix did not rub off on sheets and
> clothing, like the first batch did. (I put this on in the evening after
> a long soak in hot tub or bathtub)
>
> In pondering how to do this I remembered the SKIN MD that I had bought
> to try on the poison ivy...it said it was a skin shield!
> I tried it and it worked like a charm....in fact it only comes off
> after soaking in the tub.....
> __________________
> SALLY
> ww.psoriasis.org/forum/showthread.php?t=19572