Psoriasis support - GLA and EPA

Author

GLA and EPA

manfred

2006-10-12, 8:29 am

Has anybody tried these to block Arachidonic Acid?

Clin Ther. 2003 Mar;25(3):948-71.
Inhibition of leukotriene synthesis, pharmacokinetics, and tolerability
of a novel dietary fatty acid formulation in healthy adult subjects.

BACKGROUND: Numerous studies have explored dietary-management
strategies for decreasing leukotriene synthesis by inflammatory cells
through supplementation with polyunsaturated fatty acids such as
gamma-linolenic acid (GLA) and eicosapentaenoic acid (EPA). OBJECTIVES:
This study sought to determine the optimal daily intake, ratios, and
formulation of dietary GLA and EPA required to safely reduce
leukotriene biosynthesis in healthy individuals, and to evaluate the
pharmacokinetics and safety profile of such a formulation. METHODS: Two
preliminary trials were conducted to determine the minimum effective
levels of GLA and EPA intake needed to reduce leukotriene biosynthesis
and prevent increases in plasma arachidonic acid (AA) concentrations.
These preliminary trials were followed by a single-center, randomized,
double-blind, placebo-controlled, parallel-group, escalating-intake
inpatient trial of a dietary GLA/EPA emulsion (PLT 3514) in healthy
adult subjects. Subjects consumed either 10, 20, or 100 g of the PLT
3514 emulsion (respectively containing 0.75 g GLA + 0.5 g EPA, 1.5 g
GLA + 1 g EPA, and 7.5 g GLA + 5 g EPA), or a placebo emulsion
containing olive oil daily for 14 days. Plasma fatty acids were
measured by gas chromatography Stimulated whole blood leukotrienes were
measured by high-performance liquid chromatography with ultraviolet
detection. RESULTS: Thirty subjects were included in the preliminary
trials; 47 subjects were enrolled in the escalating-intake trial, of
whom 42 completed the study. In the preliminary trials, intake of GLA
1.5 g/d in gelatin capsules decreased the capacity to synthesize
leukotrienes but increased plasma levels of AA (both, P < 0.05).
Inclusion of 0.25 or 1 g of dietary EPA prevented the increase in
plasma AA concentrations. Dietary GLA and EPA showed significantly
enhanced bioavailability when consumed in 20 g PLT 3514 emulsion
compared with consumption in gelatin capsules (P < 0.05), resulting in
a reduction in the amount of intake required to block leukotriene
biosynthesis. Pharmacokinetic analyses indicated that fasting plasma
GLA and EPA levels plateaued within 7 days' daily consumption at all
levels of intake, whereas the time to maximum plasma concentration
(Tmax) was shorter for GLA than for EPA. The Tmax was similar on days 1
and 14 for both GLA and EPA. There were no clinically significant
between-group differences in changes in vital signs, mean clinical
laboratory values, or abbreviated hematology laboratory tests, or
significant differences in the occurrence of treatment-emergent adverse
events between the group consuming up to 20 g/d of the GLA/EPA emulsion
and the group consuming placebo. CONCLUSION: Consumption of specific
proportions and intake levels of dietary GLA and EPA in a novel
emulsion formulation inhibited leukotriene biosynthesis and appeared to
be well tolerated in this population of healthy adult subjects.

I hate to keep "beating an old horse" (awful expression) but I am
wondering if these might be part of "Uwe-know-who's so called cure.
What do chronic fatigue, psoriasis, heart attacks, strokes, and even
cancer have in common? Inflammation.

JXStern

2006-10-12, 4:28 pm

On 12 Oct 2006 03:11:32 -0700, "manfred" <manfred95@lycos.com> wrote:

>Has anybody tried these to block Arachidonic Acid?

I was big on primrose oil for the GLA content, but the body will make
its own GLA in normal circumstances, and since I've been taking
turmeric, seems I can do without the primrose oil.

Crux of this article seems to be that GLA without EPA only raised AA,
so if you take the primrose oil, eat some salmon or tuna with it, I
guess, or take a marine omega-3 capsule.

J.

randall

2006-10-12, 4:28 pm

On Oct 12, 3:11 am, "manfred" <manfre...@lycos.com> wrote:
> Has anybody tried these to block Arachidonic Acid?

YES. Since the mid 90's and I cleard half of about a 30% plus pasi in a
few months by tossing the soy bean
oil out of the pantry. Went stricly olive oil for the most part.
Figured i'd found the grail. But plateaued around
month 3-4 and slowly rebounded. But this was a powerful motivation to
use diet to clear P inflammation and
lead to my gut experiments which took me to sub 7% levels ever since.
Except when i add n-6 oils back
in as a trial with my current regime.

>
> Clin Ther. 2003 Mar;25(3):948-71.
> Inhibition of leukotriene synthesis, pharmacokinetics, and tolerability
> of a novel dietary fatty acid formulation in healthy adult subjects.

<sniP>

Let's get the link.

http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum

Studying the authors (click their names) is somewhat helpful.

Let's look at that emulsion,
http://72.14.253.104/search?q=cache...A/EPA+emulsion+(PLT+3514)&hl=en&gl=us&ct=clnk&cd=4

If it blocks D5d, then what the heck? It's worth trying.

Lets see what udo says about gla and flax.

Udo erasmus uses flax and gla to protect his PG (prostrate gland).

I guess he's more concerned with the joy stick then more vital organs.
LOL
Or one is less vital without the other fully functional. LOL

While we are tuned in to skin and AA machinations, the vital organs
will be served well by
our decisions in this arena.

Let's face it those psoriatic slurPPing down the soy bean oils or other
high n-6 fats are severe because they do.

It's no wonder severe psoriatics are more prone to heart attacks!

Back to udo and his PG.

http://www.udoerasmus.com/articles/...ax_prostate.htm

[...]

* I do not use, and recommend against the use of flax oil by
itself, but do recommend this n-3-rich oil in combination with n-6
richer oils to get the n-3/n-6 ratio right. Flax is a great source of
essential n-3 but is deficient in the equally essential n-6.
* The prostate gland appears to be quite sensitive to environmental
toxins. Among these may be plasticisers and contaminants present in
plastics. Because of environmental concerns and our very limited
knowledge of the effects of these molecules on health, I recommend
against using plastics for packaging, especially liquids (water, oil,
milk, juices, vinegar, alcohol, tinctures, etc.). Liquids move,
continually washing the inside of their container. Any molecules
present in plastic containers (fillers, plasticisers, stabilizers,
mould releasers, slip agents, sheen agents, contaminating metals such
as lead (Pb) or aluminum (Al)), which might dissolve in the liquid
contained, may drift from the plastic into the food. Drift of molecules
from plastic into liquid is the reason why water in plastic bottles can
acquire a 'plastic' taste.
* One is less likely to taste plastic in oils than in water.
However, due to the chemical similarity of oil molecules and plastic
molecules, oils swell plastics, opening pores in this non-natural
synthetic material that make the drift of such molecules into oils even
more likely than the drift of molecules from plastic into water.
* I do use and recommend an oil blend containing flax with
sunflower and sesame oils from organically grown seeds, made with
health in mind, and in the right n-3: n-6 ratio to prevent n-6
deficiency. In fact, I created the formula for such a blend, and I use
it daily with my food.
* I do insist that my oil blend is packed in brown glass, further
protected by a box to keep out all light, and further protected by
refrigeration in factory, store, and home to extend freshness.
* I also use and recommend zinc, selenium, antioxidants,
phytosterols, saw palmetto, broccoli and other cruciferous vegetables,
anti-inflammatory herbs, and maitake extracts or mushrooms as part of a
prostate nourishing nutritional program.
* I use and recommend optimum intake of all components of health:
20 minerals; 14 vitamins; 8-11 essential amino acids; 2 essential fatty
acids; detoxifying fiber; digestive enzymes; friendly bowel
microorganisms; antioxidants; herbs (phytonutrients); filtered water;
clean air; sunlight; and fuel.
* I engage in and recommend physical activity (work or exercise) to
stay fit. I indulge myself in and recommend rest; sufficient sleep;
recreation; the passionate pursuit of worthwhile goals; time spent with
friends; a sense of humor; good balance between work and play;
heart-felt gratitude; and faith in the grand scheme of things.
* I use ALA on a daily basis, combined with LA in my oil blend, as
part of my program for health, along with lots of fresh organic green
foods, proteins, support for digestion, and carbohydrate intake limited
to the amount I burn. I take supplements of minerals, vitamins,
antioxidants, and herbs.
* I do not worry about ALA from oils made with health in mind
causing me prostate cancer. After all, common sense insists and
research confirms that ALA (undamaged and accompanied by sufficient
undamaged LA and natural antioxidants), is essential for life and for
health.

[...]

(Essential) N-3 = omega-3 fatty acids include:

1. ALA (alpha-linolenic acid; abundant in flax, and present in
small quantities in hemp, walnut, soybean, and canola); given enough
ALA to start with, the body converts ALA into SDA, EPA, and DHA in
various tissues, according to need; conversion varies, depending on
several factors, and ranges from less than 5% to 36% per day of the
amount of ALA consumed;
2. SDA (stearidonic acid; present in a few exotic seeds);
3. EPA (eicosapentaenoic acid; parent of Series 1 eicosanoid
hormones; found in fish oils);
4. DPA (docosapentaenoic acid);
5. DHA (docosahexaenoic acid; the major brain n-3; also found in
eyeball (retina), red-brown algae, and fish oils).

ALA = Alpha-Linolenic Acid is the omega 3 (n-3) EFA. It is sometimes
shortened to LNA.
ALA is very fragile to destruction by light, oxygen (air), and heat,
and must therefore be protected from these influences. If this is not
done, ALA molecules change from natural and beneficial to unnatural and
toxic. ALA is destroyed about 5 times faster than LA, the n-6 EFA.

ALA is deficient in the diets of most people in affluent societies. Due
to processing damage, shelf life considerations, and changes in food
choices, average intake of n-3 has decreased to less than 20% of what
was present in common diets 150 years ago. Even back then, n-3 intake
was less than optimal because only a few foods are rich in n-3.

About 90-95% of the population gets less n-3 than required for good
health (making n-3 the essential nutrient most often lacking in
people's foods) and n-3 is therefore the most therapeutic of all of the
essential nutrients (20 minerals, 14 vitamins, 8-11 amino acids, 2
fatty acids).

[...]

(Essential) N-6 = omega-6 fatty acids include:

1. LA (linoleic acid; abundant in safflower, sunflower, and corn;
present in medium quantities in soybean, sesame, pumpkin seed, and
almond; present in small quantities in canola, peanut, and olive);
given enough LA to start with, the body converts LA into GLA, DGLA, and
AA in various tissues, according to need;
2. GLA (gamma-linolenic acid; present in evening primrose oil); GLA
can partially cover n-3 deficiency; a main reason for its benefits
comes from being used in an n-3 deficient population; in people
consuming an n-3-rich, n-6-balanced diet, GLA is not nearly as
impressive as it is in treating n-3 deficient people;
3. DGLA (dihomogamma-linolenic acid; parent of Series 1 eicosanoid
hormones);
4. AA (Arachidonic acid; the major brain n-6; parent of Series 2
eicosanoid hormones; found in meat, eggs, and dairy products).

---------------------------------------------------------------

Wow! Number 1. i'm not worried about the plastic bottles. #2 if the
flax seed oil is a 4 to 1, n-3 to n-6 profile then
i'm happy to take it for 8 months to re-balance out my ratio. # 3 if
taking some gla makes it work faster better etc,
then count me in.

As posted previously i'm not only taking fish oils, cod liver oil and
flax, but my flax blend now has borage for
gla considerations.

GEE!

NO, GLA! LOL

----------------------------------

Manfred said:

.. CONCLUSION: Consumption of specific
> proportions and intake levels of dietary GLA and EPA in a novel
> emulsion formulation inhibited leukotriene biosynthesis and appeared to
> be well tolerated in this population of healthy adult subjects.
>
> I hate to keep "beating an old horse" (awful expression) but I am
> wondering if these might be part of "Uwe-know-who's so called cure.
> What do chronic fatigue, psoriasis, heart attacks, strokes, and even
> cancer have in common? Inflammation.

Hey! Don't ask a question and then give us the answer! lol

Your no fun.

How about why do we skew so far to the th1 side and those with similar
fatty lipids in their diets end up with a Th2 skew and cancer?

Is it due to a compensatory mechanism or just bad (good for fighting
cancer though) genes?

And will old time herbals like boswellic acids (Frankincense) help both
conditions?

http://www.ncbi.nlm.nih.gov/entrez/...l=pubmed_docsum

P Group links to bowsellia,
http://groups-beta.google.com/group...sis&q=boswellia

And if it doesn't clear P, does that mean the problem is still in the
gut somewhere?

Yet, isn't it easier to stop eating these n-6 fats? And simply clear if
that is your main pathway?

Yet, if gut permeability is a factor then LPS (endotoxin) will still be
a factor in TNF generation?

And is it possible with diet to become clear?

randall... i'm nearly there. Grail time! LOL and loving it!