Psoriasis support - Did someone mention iron here recently?

Author

Did someone mention iron here recently?

Fizziwig2

2005-09-24, 1:41 pm

http://news.bbc.co.uk/1/hi/health/4225610.stm

"Iron absorption mystery 'solved'

Scientists say they have worked out how the gut absorbs iron from meat into
the blood - a discovery they hope could lead to new treatments for anaemia.
A key protein appears to control the process in mice, the King's College
London team told the journal Cell.

Mutations in the protein could affect the ability to absorb iron, they said.

Iron deficiency, which causes tiredness, is the world's most common
nutritional problem. In the UK around 20% of women are anaemic.".

..Snip.............................

Haem iron is absorbed around five times more efficiently than inorganic
iron - this is why eating red meat is recommended for preventing anaemia.

But until now the way in which haem iron was taken up in the gut had been
unknown.

By studying mice with anaemia, the King's team has identified a transporter
protein, called HCP1, which appears to solve the riddle.

Shifting position

They found the protein was active in the first part of the intestine, the
duodenum, and that it shifted position within the intestinal cells in
response to changes in the body's iron stores, allowing cells to take up
more, or less, haem as required.

more there........

My mother suffered from pernicious anaemia so we all raised on liver, liver,
liver til I got sick of it (for the B12).

Fizziwig2

2005-09-24, 1:41 pm

"Fizziwig2" <atthebackofthenorthwind@kingdomcom.co.uk> wrote in message
news:3JgVe.107274$G8.27770@text.news.blueyonder.co.uk...
> http://news.bbc.co.uk/1/hi/health/4225610.stm
>
> "Iron absorption mystery 'solved'
>
> Scientists say they have worked out how the gut absorbs iron from meat
> into the blood - a discovery they hope could lead to new treatments for
> anaemia.
> A key protein appears to control the process in mice, the King's College
> London team told the journal Cell.
>
> Mutations in the protein could affect the ability to absorb iron, they
> said.
>
> Iron deficiency, which causes tiredness, is the world's most common
> nutritional problem. In the UK around 20% of women are anaemic.".
>
> .Snip.............................
>
> Haem iron is absorbed around five times more efficiently than inorganic
> iron - this is why eating red meat is recommended for preventing anaemia.
>
> But until now the way in which haem iron was taken up in the gut had been
> unknown.
>
> By studying mice with anaemia, the King's team has identified a
> transporter protein, called HCP1, which appears to solve the riddle.
>
> Shifting position
>
> They found the protein was active in the first part of the intestine, the
> duodenum, and that it shifted position within the intestinal cells in
> response to changes in the body's iron stores, allowing cells to take up
> more, or less, haem as required.
>
> more there........
>
> My mother suffered from pernicious anaemia so we all raised on liver,
> liver, liver til I got sick of it (for the B12).
>

BTW they mention Haemochromatosis in the artile and there is a combination
article I found here.
http://www.ihwg.org/components/hpover.htm

"Haemochromatosis, Psoriasis Vulgaris and Other Diseases Associated with HLA
Class I Alleles

Background
Some HLA - disease associations appear to involve Class I rather that Class
II. Haemochromatosis has been known to be associated with HLA-A3 and other
polymorphic markers telomeric of HLA-A. In 1996, the C282Y mutation of the
HFE gene was shown to be the best marker for the disease (Feder et al.
1996). Recently it was reported that a mutation of the HFE gene is found
commonly but not universally in patients. The HFE gene is similar to PERB11
(MIC), Zinc-alpha-2-glycoprotein, neonatal Fc Receptor and HLA Class I (Tay
et al. 1997). It remains to be shown whether HFE or other similar genes are
involved directly in the pathogenesis of haemochromatosis, but it seems
likely that the mechanism will be unraveled during the course of the
workshop. A recent paper in Nature described the crystal structure of HFE
and its binding to transferrin receptor (Bennett et al. 2000).

Psoriasis has been associated with HLA-Cw6 (Tiilikainen et al. 1980), but
again there are associations with other polymorphisms telomeric or close to
HLA-B. Several candidate genes are being investigated actively. These
include the S gene, SC1, Pg8 and PERB11(MIC). We have recently shown that
PERB11 (MIC) is present in the epidermis including ducts and follicles in
normal and affected skin and we therefore suggest a role for PERB11 and
other MHC genes in the pathogenesis of psoriasis (Tay et al. 2000). Oka and
colleagues have also localised the susceptibility region for Psoriasis
Vulgaris telomeric to the HLA-C gene (Oka et al. (In Press))."

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