| randall 2005-09-24, 1:40 pm |
| Hi Uwe and Maurice,
There are alcohol problems for psoriatics.
A chicken or egg droP souP thing for sure.
http://www.ncbi.nlm.nih.gov/entrez/...t_uids=15180464
We have some LDN threads,
http://groups.google.com/group/alt....arch+this+group
http://www.ncbi.nlm.nih.gov/entrez/...ct&list_uids=15
[Antipruritic therapy with the oral opioid receptor antagonist
naltrexone. Open, non-placebo controlled administration in 133
patients]
[Article in German]
Brune A, Metze D, Luger TA, Stander S.
Klinik und Poliklinik fur Hautkrankheiten, Universitatsklinikum
Munster.
BACKGROUND AND OBJECTIVES: The perception of pruritus is modified by
endogenous and exogenous opioids via central opiate receptors and can
be suppressed with opioid receptor antagonists. The aim of this
investigation was to describe the efficacy and safety of naltrexone, an
orally active opiate antagonist, in the treatment of severe, otherwise
intractable pruritus of varying origins. PATIENTS: A total of 133
patients with pruritus caused by inflammatory skin diseases (asteatotic
dermatitis, atopic dermatitis, prurigo, and psoriasis vulgaris), liver-
and renal diseases, cutaneous lymphoma, as well as with pruritus of
unknown origin were treated with naltrexone (Nemexin) 50 to 150 mg
daily. RESULTS: A therapeutic response was achieved in 86 of the 133
(64.6%) patients. Naltrexone was most effective in prurigo nodularis,
cutaneous lymphoma and pruritus of unknown origin. Tachyphylaxis
occurred in 13% of the patients, but appeared late, and could be
counterbalanced by raising the dosage. Adverse drug effects were
restricted to the first two weeks of treatment and included mainly
neurological (dizziness, headache, fatigue) and gastrointestinal
(nausea, vomiting, diarrhea) symptoms. CONCLUSIONS: The oral opiate
antagonists may well be an effective, well-tolerated therapy for
intractable pruritus in many diseases.
PMID: 15517116
(This same group of researchers did a similar trial five years earlier
with half as
many patients)
If it's was uP to me i'd do a FAE and LDN test for P heads tomorrow.
Sadly, it's not.
Happily i'm doing wonders with IP6 and high dose vitamin C right now.
(caveats_ on top of my randall's whey diet and supplements )
Sure LDN would help a greater then 50% of psoriatic population.
Is it a cure?
I doubt it or we'd know from former psoriatics.
You want an ePiPhany?
We all do.
randall... still working on it.
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